Results 131 to 140 of about 3,663,081 (289)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Ethical values as the foundation of human actions
Zdravniški Vestnik, 2016 Introductory lecture at the expert workshop entitled »Etics at the Crossroads« heldwithin the 152nd regular annual assembly of the Slovenian Medical Association inMoravske ...
Borut Ošlaj
doaj
Modeling and Predicting Human Actions in Soccer Using Tensor-SOM
Applied SciencesAs robots become increasingly integrated into society, a future in which humans and robots collaborate is expected. In such a cooperative society, robots must possess the ability to predict human behavior.
Moeko Tominaga +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
REVIEW OF THE HUMAN ACTIONS AS LEGAL FACTS IN THE PROPERTY LAW
Iustinianus Primus Law Review, 2019 The legal facts have always been of interest to the legal scientists, since the creation, the modification and the termination of the civil law depend on them.
Ilina Stefanovska Zdravevska
doaj
Pesonal Causality in Human Action
Forum. Supplement to Acta Philosophica, 2019 The study of causality in the natural sciences has always been posed from observing the e ect and looking for the cause in a previous time. The principle of causality is caught in a vicious circle based on two assumptions of Kantian origin: (1) causality is a structuring principle of the human mind. (2) In the cause-e ect relation, the cause temporally
openaire +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source