Results 111 to 120 of about 9,548,283 (235)
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Demographic Risk to Eagles from Anthropogenic Causes of Death
Пернатые хищники и их охрана, 2018 Human actions effect wildlife in both indirect and direct ways. Indirect processes – habitat loss, climate change, reductions in reproductive rates – are often difficult to quantify.
Todd Katzner +5 more
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Is Britain Fairer?: The State of Equality and Human Rights in Britain [PDF]
, 2015 This is our five-yearly report on equality and human rights progress in Great Britain. The report sets out our findings and the challenges for the future in the following areas: - education and learning - work, income and the economy - health and care -
Equality and Human Rights Commission,
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Point-light biological motion perception activates human premotor cortex [PDF]
, 2004 Motion cues can be surprisingly powerful in defining objects and events. Specifically, a handful of point-lights attached to the joints of a human actor will evoke a vivid percept of action when the body is in motion.
Hagler, DJ +9 more
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
مدیریت بهره وریapproach focusing on involvement in decisions, can increase the ability, skill and creativity of employees and their internal morale and motivation. This research was conducted to provide a model for human resource management with high involvement in ...
Monireh Abdi +2 more
doaj
Ethical values as the foundation of human actions
Zdravniški Vestnik, 2016 Introductory lecture at the expert workshop entitled »Etics at the Crossroads« heldwithin the 152nd regular annual assembly of the Slovenian Medical Association inMoravske ...
Borut Ošlaj
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