Results 91 to 100 of about 3,663,081 (289)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

İBRAHİM EL-KÛRÂNÎ’NİN HÂDİS KUDRETİ TASAVVURU VE ABDÜLGANÎ EN-NABLUSÎ’NİN ELEŞTİRİLERİ

open access: yesKocaeli İlahiyat Dergisi, 2018
İbrâhim el-Kûrânî, kelâm ve tasavvuf geleneğinin XVII. yüzyıldaki önemli isimlerindendir. Kûrânî’nin kelâm, tasavvuf ve hadis gibi alanlarda telif ettiği risaleler, kendisi hayattayken İslam dünyasının farklı bölgelerinde yaşayan âlimlere ulaşmış ve ...
Şerife Nur Çelik
doaj  

Accurate Hierarchical Human Actions Recognition From Kinect Skeleton Data

open access: yesIEEE Access, 2019
Human action recognition has become one of the most active research topics in natural human interaction and artificial intelligence, and has attracted much attention.
Benyue Su   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

KUR’AN’A GÖRE KADER MESELESİNE BİR BAKIŞ

open access: yesBartın Üniversitesi İslami İlimler Fakültesi Dergisi, 2017
İnsanlık tarihinin en önemli meselelerinden biri kader meselesidir. Buna bağlı olarak herhangi bir oluşun özellikle de insan tercihlerinin, ezelden Allah tarafından belirlenmiş olup olmadığı ya da bilinip bilinmediği konusu ilk sırayı alır. Bu çalışmanın
Mustafa Özden
doaj  

Risks, ex-ante actions, and public assistance: Impacts of natural disasters on child schooling in Bangladesh, Ethiopia, and Malawi [PDF]

open access: yes
"This paper uses panel data from Bangladesh, Ethiopia, and Malawi to examine the impacts of natural disasters on schooling investments, with a particular focus on the roles of ex-ante actions and ex-post responses.
Quisumbing, Agnes R.   +2 more
core  

Extending the use of plateau-escaping macro-actions in planning [PDF]

open access: yes, 2006
Many fully automated planning systems use a single, domain independent heuristic to guide search and no other problem specific guidance. While these systems exhibit excellent performance, they are often out-performed by systems which are either given ...
Smith, Amanda
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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