Results 141 to 150 of about 151,130 (306)

Biosensing With Nanofluidics

Exploration, EarlyView.
Nanofluidic biosensors employing in‐plane, out‐of‐plane, and free‐plane architectures transduce biomolecular information into fluidic signals through nanoscale manipulation of confined fluids, offering a quantitative and highly sensitive platform for biochemical detection. ABSTRACT Nanofluidics, the study of fluid transport confined within nanochannels
Qun Ma, Yan Xu
wiley   +1 more source

Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology

Exploration, EarlyView.
Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen, Wenzhe Yi, Rongzhang Li, Shuangshuang Hu, Xindi Qian, Dan Yan, Qian Zou, Guanru Wang, Yaping Li   +8 more
wiley   +1 more source

Transductional retargeting of human adenovirus type 5 to ανβ6 integrin for cancer gene therapy

, 2009
PhDA key impediment to successful cancer therapy with adenoviral vectors is the inefficient transduction of malignant tissue in vivo. Compounding this problem is the lack of cancer-specific targets, coupled with a shortage of corresponding high ...
Coughlan, Lynda
core  

Estudo da incidência de adenovírus humano e suíno, norovírus humano e circovírus suíno, em amostras de água de consumo e descedentação animal do município de Concórdia, Santa Catarina [PDF]

, 2011
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Os dejetos provenientes da suinocultura e da população podem potencialmente contaminar mananciais de captação de água para consumo, já que esses efluentes ...
Garcia, Lucas Ariel Totaro
core  

Mitochondrial DNA from hamster tumors induced by adenovirus type 12

, 1970
1. Mitochondria isolated from hamster tumors induced by adenovirus type 12 possessed circular DNA fibers. 2. The mean value of the length of the highest frequency group of the circular DNA molecules was 4.92 ±0.38 μ. 3. Catenated dimer DNA molecules
Oda, Takuzo, Nishida, Shigeru
core   +1 more source

Modification of the E1-pIX region of the adenovirus 5 genome for use in cancer gene therapy

, 2008
Currently the use of adenoviruses in cancer gene therapy is limited by efficient delivery of the virus into the tumour cells, detargeting of the virus from the liver, and the efficient spread of the virus within the tumour.
Kallioinen, Susanna E.
core  

Markedly enhanced intratumoral spread and antitumor effect of oncolytic adenovirus expressing decorin

, 2008
With the aim of improving viral distribution and tumor penetration, we have engineered decorin expressing replication-incompetent (dl-LacZ-DCNG) and -competent (Ad-[DELTA]E1B-DCNG) adenoviruses.
Joo-Hang Kim, Hoguen Kim, Chae-Ok Yun, A-Rum Yoon, Daniela G. Seidler, Ji Young Yoo, Il-Kyu Choi, Young-Sook Lee   +7 more
core  

Construction of a bivalent vaccine candidate against HAdV4/HAdV7 based on capsid-display strategy via Red-homologous recombination and counter-selection methodology

Biosafety and Health
Human adenoviruses (HAdVs) are major respiratory pathogens. Specifically, human adenovirus type 4 (HAdV4) and human adenovirus type 7 (HAdV7) are known for causing fever and pneumonia, with documented cases of fatalities among the population.
Peng Wang, Yunting Shao, Xichun Yang, Wenning Zhang, Jianguang Zhou, Fang Huang, Shuang Liu, Jiping Zheng, Chengjun Wu, Shanhu Li   +9 more
doaj   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source