Results 121 to 130 of about 151,130 (306)

The potential of a novel Adenovirus vector for vaccination [PDF]

Adenoviruses (Ads) have many attractive characteristics for use as agents of genebased vaccines and therapies. The most frequently used Ad vectors in preclinical research are based on Ad5.
Martin, Stuart
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The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

The transmembrane domain of the adenovirus E3/19K protein acts as an ER retention signal and contributes to intracellular sequestration of MHC class I molecules [PDF]

, 2013
The human adenovirus E3/19K-protein is a type-I transmembrane glycoprotein of the endoplasmic reticulum (ER) that abrogates cell-surface transport of MHC class-I (MHC-I) and MICA/B-molecules.
Ruszics, Zsolt, Burgert, Hans-Gerhard, Mackley, Emma, Sester, Martina   +3 more
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Adenoviral Keratoconjunctivitis

Sultan Qaboos University Medical Journal, 2007
Acute epibulbar infections in humans are one of the most frequently diagnosed eye diseases. The majority of these are thought to be caused by the adenovirus.
Alexander Bialasiewicz
doaj  

Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity

Viruses, 2016
Human adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections.
Glen R. Nemerow, Phoebe L. Stewart
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice

, 2006
Recombinant adenovirus (rAd)-mediated apoE gene transfer to the liver of apoE(-/-) mice is anti-atherogenic. However, first generation rAd vectors were associated with immune clearance of transduced hepatocytes, while an improved [E1(-), E3(-) polymerase(
Amalfitano, A, Owen, JS, Dickson, G, Graham, IR, Harris, JD   +4 more
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Adenovirus-Mediated Sensitization to the Cytotoxic Drugs Docetaxel and Mitoxantrone Is Dependent on Regulatory Domains in the E1ACR1 Gene-Region

, 2012
Oncolytic adenoviruses have shown promising efficacy in clinical trials targeting prostate cancers that frequently develop resistance to all current therapies.
Halldén Gunnel, Miranda, Enrique, Maya Pineda, Hector, Oeberg, D, Cherubini Gioia, Zita Garate (130698), Maya Pineda Hector, Gunnel Halldén, Lemoine Nick R., Öberg, Daniel,, Nick R. Lemoine (130704), Lemoine, NR, Maya Pineda, H, Gunnel Halldén (130708), Nick R Lemoine, Gioia Cherubini, Daniel Öberg (130690), Halldén, G, Miranda Enrique, Garate Zita, Hector Maya Pineda, Öberg Daniel, Garate, Zita, Garate, Z, Zita Garate, Enrique Miranda (130684), Pineda, HM, Daniel Öberg, Halldén, Gunnel, Enrique Miranda, Öberg, D, Lemoine, Nick R, Hector Maya Pineda (130688), Cherubini, Gioia, Gioia Cherubini (130694), Miranda, E, Cherubini, G   +36 more
core   +1 more source

Risk of venous thromboembolism after SARS‐CoV‐2 vaccination—Evidence from genome‐wide association study and population‐based observational study

British Journal of Clinical Pharmacology, EarlyView.
Aim We aimed to investigate whether genetic variation is associated with venous thromboembolism after immunization with SARS‐CoV‐2 vaccines. Methods We conducted a genome‐wide association study (GWAS) on cases of venous thromboembolism within 42 days after SARS‐CoV‐2 vaccination, recruited from reports of adverse drug reactions sent to the Swedish ...
Sofia Attelind, Niclas Eriksson, Marco Cavalli, Yiyi Xu, Fredrik Nyberg, Anders Sundström, Mia Wadelius, Pär Hallberg   +7 more
wiley   +1 more source

Carrier cell-mediated cell lysis of squamous cell carcinoma by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus

, 2009
The squamous cell carcinoma antigen (SCCA) serves as a serological marker for squamous cell carcinomas. Molecular cloning of the SCCA genomic region has revealed the presence of two tandemly arrayed genes, SCCA1 and SCCA2.
Yoshiyuki Koyama, Hiroyuki Hamakawa, Hiroshi Ito, Kenzaburo Tani, Junzo Desaki, Ting Zhang, Katsuyuki Hamada, Koh-ichi Nakashiro   +7 more
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