Results 101 to 110 of about 151,130 (306)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Surveillance of adenoviruses and noroviruses in European recreational waters [PDF]

, 2011
Exposure to human pathogenic viruses in recreational waters has been shown to cause disease outbreaks. In the context of Article 14 of the revised European Bathing Waters Directive 2006/7/EC (rBWD, CEU, 2006) a Europe-wide surveillance study was carried ...
SELLWOOD J, LÓPEZ PILA J, Cook, N, Cook, Nigel, KAY D, D'AGOSTINO M, DE RODA HUSMAN AM, Höller, Christiane, KOZYRA I, Salagnonc, E, Juan López-Pila, Kay, D, Michele Muscillo, Clementeh, P, Schneidere, O, WYN JONES AP, Roda Husman, Ana Maria de, WYER M., Lopez Pila, J, D’Agostino, M, Orgorzalyf, L, GIRONES R, Gräberl, I, Wildegm, S., Maurizio Divizia, Christiane Höller, DONIA, DOMENICA TOMMASA, George Papageorgiou, De Roda Husman, AM, Sao José Nascimento, M, Rosina Girones, Ana Maria de Roda Husman, Sellwood, J, Duarten, A, Veranib, M, A. Peter Wyn-Jones, FLEISCHER J, José Nascimento, Maria São, Annalaura Carducci, Mark Wyer, significant contributions by Bofill Mash, S, Gawler, Andrew, GANTZER C, Lopez-Pila, J, D’agostino, Martin, MUSCILLO M, Jens Fleischer, Hoeller, C, Huberi, S, Divizia, Maurizio, Muscillo, M, GAWLER A, Nascimento, Maria, PAPAGEORGIOU G, Martin D’Agostino, Hollisterp, W, Rosannad, G, Christophe Gantzer, SZEWZYK R, de Roda Husman, Ana Maria, Wyn-Jones, AP, COOK N, Rutjes, Saskia, Donia, DT, David Kay, HÖLLER C, Cuvelierk, B, Carducci, Annalaura, Rutjes, S, Docters van Leeuwenj, A, Wyer, M, Kozyra, I, Gantzer, C., Kozyra, Iwona, Muscillo, Michele, significant contributions by Bofill-Mash, S, Girones, Rosina, Carducci, A, Sellwood, Jane, Szewzyk, Regine, Girones, R, Kay, David, DIVIZIA M, RUTJES S, Gironès Llop, Rosina, Maria São José Nascimento, López-Pila, Juan, Wyn Jones, AP, JOSÉ NASCIMENTO MS, Pissarides, N, Szewzyk, R, Gantzer, C, Nigel Cook, Papageorgiou, George, La Rosam, G, Wyn-Jones, A. Peter, Iwona Kozyra, Iaconellim, M, Gantzer, Christophe, Andrew Gawler, Papageorgiou, G, Fleischer, Jens, Regine Szewzyk, Divizia, M, Gawler, A, Saskia Rutjes, Wildegm, S, Jane Sellwood, Wyer, Mark, D'Agostino, Martin, Fleischer, J   +110 more
core   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Intracranial transplantation of the tumor induced by adenovirus type 12 in Syrian hamster--an experimental brain tumor model

, 1971
A method of intracranial transplantation of the tumor induced by adenovirus type 12 in syrian hamster has been described. The incidence of intracranial tumor development was 86 (90.5 %) out of 95 animals and the average survival time and tumor size at ...
Tabuchi, Kazuo
core   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker [PDF]

, 2010
The oncolytic adenovirus dl922-947 replicates selectively within and lyses cells with a dysregulated Rb pathway, a finding seen in > 90% human cancers.
Balkwill, F.R., Magdalena B Flak, Balkwill, FR, Chelala, C, McNeish, IA, Archibald, Kyra, Pirlo, K.J., Chelala, C., Iain A McNeish, Flak, M.B., Salako, MA, Pirlo, KJ, Katrina J Pirlo, Salako, M.A., Lockley, M, Connell, C.M., Mcneish, I.A., Lockley, M., Wheatley, S.P., Wheatley, SP, Flak, Magdalena B; id_orcid, Archibald, K, Archibald, K., Flak, MB, Michael A Salako, Michelle Lockley, Claude Chelala, McNeish, Iain A, Kyra Archibald, Frances R Balkwill, Pirlo, Katrina J, Lockley, Michelle, Connell, CM, Sally P Wheatley, Chelala, Claude, Balkwill, Frances R, Connell, Claire M, Claire M Connell, Salako, Michael A, Wheatley, Sally P   +39 more
core   +1 more source

In vitro and in vivo tropism and biodistribution of recombinant simian adenovirus type 25

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Recombinant adenoviruses are widely used in the development of vaccines for a variety of infectious diseases. Despite numerous clinical studies, only a few types of human (types 5 and 26) and simian (isolate Y25) adenoviruses are currently ...
Irina V. Vavilova, Tatiana A. Ozharovskaia, Olga V. Zubkova, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Denis I. Zrelkin, Alina Sh. Dzharullaeva, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg   +11 more
doaj   +1 more source

Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein

Viruses, 2015
Human adenovirus type 55 (HAdV55) is a newly identified re-emergent acute respiratory disease (ARD) pathogen with a proposed recombination of hexon gene between HAdV11 and HAdV14 strains.
Xingui Tian, Qiang Ma, Zaixue Jiang, Junfeng Huang, Qian Liu, Xiaomei Lu, Qingming Luo, Rong Zhou   +7 more
doaj   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Adenovirus ?Hit-And-Run? Eviction From B-Cells Harboring Leukemic Runx1 Fusion Genes And Adp Controlled Latency In Lymphocytes

, 2021
The common species C adenoviruses infect more than 80% of the human population early in life. The virus can establish an asymptomatic persistent infection in mucosal-associated lymphocytes.
Wilms, Hans T
core   +1 more source