Molecular Switching in Human Adenovirus [PDF]
Biophysical Journal, 2012 Human Adenovirus (Ad) is an icosahedral, double stranded DNA virus. Activating the assembly of viral particles requires at least three viral components: the IVa2 and L4-22K proteins, as well as a section of DNA within the viral genome, called the packaging sequence (PS). Previous studies have shown that the IVa2 and L4-22K proteins specifically bind to
Maluf, Nasib K., Yang, Teng-Chieh
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Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]
, 1994 The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G. +8 more
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Almost famous: Human adenoviruses (and what they have taught us about cancer)
Tumour Virus Research, 2021 Papillomaviruses, polyomaviruses and adenoviruses are collectively categorized as the small DNA tumour viruses. Notably, human adenoviruses were the first human viruses demonstrated to be able to cause cancer, albeit in non-human animal models.
Tanner M. Tessier +5 more
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Circumventing antivector immunity: potential use of nonhuman adenoviral vectors [PDF]
, 2014 Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase
Beard C.W. +30 more
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Humanized Mice Reproduce Acute and Persistent Human Adenovirus Infection [PDF]
Journal of Infectious Diseases, 2016 Severe human adenovirus (HAdV) infections are an increasing threat for immunosuppressed individuals, particularly those who have received stem cell transplants. It has been previously hypothesized that severe infections might be due to reactivation of a persistent infection, but this hypothesis has been difficult to test owing to the lack of a ...
Estefanía, Rodríguez +9 more
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Adenovirus late phase infection is controlled by a novel L4 promoter [PDF]
, 2001 During human adenovirus 5 infection, a temporal cascade of gene expression leads ultimately to the production of large amounts of the proteins needed to construct progeny virions.
Morris, S. J. (Susan J.) +2 more
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Canine Hepatitis Virus and Human Adenovirus [PDF]
Public Health Reports (1896-1970), 1962 INCREASING awareness of human infectious hepatitis and the common occurrence of infectious canine hepatitis in the United States have precipitated queries about the possible transmission of the canine disease to man, particularly when illness occurs simultaneously or has similar manifestations in a pet and in a family member.
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Identification of a nonstructural DNA-binding protein (DBP) as an antigen with diagnostic potential for human adenovirus. [PDF]
PLoS ONE, 2013 BACKGROUND: Human adenoviruses (HAdVs) have been implicated as important agents in a wide range of human illnesses. To date, 58 distinct HAdV serotypes have been identified and can be grouped into six species.
Li Guo +8 more
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Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary cells in the presence of adenovirus [PDF]
, 1994 Endotoxin (lipopolysaccharide, LPS) is commonly found as a contaminant in plasmid DNA preparations. We demonstrate here that the quantities of LPS typically contaminating DNA preparations can generate a toxicity to primary cells (primary human skin ...
Baker, A. +4 more
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A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis. [PDF]
PLoS Neglected Tropical Diseases, 2018 BACKGROUND:Estimates of current global rabies mortality range from 26,000 to 59,000 deaths per annum. Although pre-exposure prophylaxis using inactivated rabies virus vaccines (IRVs) is effective, it requires two to three doses and is regarded as being ...
Chuan Wang +15 more
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