Results 41 to 50 of about 151,159 (303)

STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control. [PDF]

PLoS Pathogens, 2015
Human adenoviruses have been studied extensively in cell culture and have been a model for studies in molecular, cellular, and medical biology. However, much less is known about adenovirus replication and pathogenesis in vivo in a permissive host because
Karoly Toth, Sang R Lee, Baoling Ying, Jacqueline F Spencer, Ann E Tollefson, John E Sagartz, Il-Keun Kong, Zhongde Wang, William S M Wold   +8 more
doaj   +1 more source

Disseminated adenovirus infection in a patient with a hematologic malignancy: a case report and literature review

Future Science OA, 2019
Human adenoviruses cause a wide spectrum of illnesses, including invasive infections, in immunocompromised hosts. We report a case of disseminated adenovirus infection following unrelated cord–blood transplantation in a 46-year-old male with a lymphoma ...
Akane Takamatsu, Yasuaki Tagashira, Shinya Hasegawa, Hitoshi Honda   +3 more
doaj   +1 more source

Liver Transaminases in Pediatric Adenovirus Infection—A Five-Year Study in Two Major Reference Centers from Romania

Microorganisms, 2023
Human adenovirus causes infections with a very heterogeneous clinical picture, and children are often the most frequently affected group. Interest in adenovirus has increased with the 2022 outbreak of severe acute hepatitis of unknown etiology as human ...
Oana Săndulescu, Anca Streinu-Cercel, Victor Daniel Miron, Silvia Mirela Covăcescu, Adrian Streinu-Cercel, Mihai Craiu   +5 more
doaj   +1 more source

The structural basis for the integrity of adenovirus Ad3 dodecahedron [PDF]

, 2012
During the viral life cycle adenoviruses produce excess capsid proteins. Human adenovirus serotype 3 (Ad3) synthesizes predominantly an excess of free pentons, the complexes of pentameric penton base and trimeric fiber proteins, which are responsible for
Fender, Pascal, Monika Zochowska (134637), Jean-Pierre Andrieu, Ewa Szolajska (134629), Stephen Cusack (134664), Burmeister, Wim P, Pascal Fender (132764), Szolajska, Ewa, Pascal Fender, Nerlo, Barbara, Burmeister, Wim P., Igor Andreev, Wim P. Burmeister (134634), Wim P Burmeister, Guy Schoehn, Jadwiga Chroboczek (134668), Andreev, Igor, Naskalska, Antonina, Stephen Cusack, Chroboczek, Jadwiga, Barbara Nerlo (134643), Ewa Szolajska, Chloe Zubieta (134662), Barbara Nerlo, Igor Andreev (134649), Andrieu, Jean-Pierre, Jadwiga Chroboczek, Chloe Zubieta, Monika Zochowska, Zochowska, Monika, Cusack, Stephen, Jean-Pierre Andrieu (134655), Schoehn, Guy, Antonina Naskalska, Guy Schoehn (27525), Zubieta, Chloe, Antonina Naskalska (134660)   +36 more
core   +1 more source

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus [PDF]

, 2010
Background CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of CD40 ligation depends on the level
Young Lawrence S, Elmetwali, Taha, Mcneish, I., Searle Peter F, Young, Lawrence, Searle, PF, Palmer Daniel H, McNeish, I, Young, Lawrence S., Palmer, D.H., McNeish, Iain, Peter F Searle, Lawrence S Young, Elmetwali, T., Searle, P.F., Elmetwali Taha, Iain McNeish, Young, LS, McNeish Iain, Palmer, Daniel H., Palmer, DH, Searle, Peter F., Daniel H Palmer, Young, L.S., Taha Elmetwali, Palmer, Daniel, Searle, Peter, Elmetwali, T   +27 more
core   +1 more source

Antibody to human adenovirus early antigens during acute adenovirus infections [PDF]

Infection and Immunity, 1981
The antibody (Ab) response to human adenovirus (AV) early antigens (EA) in acute AV infections was studied by the immunoperoxidase antibody technique for determining virus-specific immunoglobulin G (IPA-IgG). AV-EA-Ab appeared about 5 days after the onset of clinical symptoms, reached a peak 15 to 30 days later, and declined in titer after a few months.
G, Gerna, E, Cattaneo, M G, Revello, M, Battaglia, G, Achilli   +4 more
openaire   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Adenovirus Early Proteins and Host Sumoylation

mBio, 2016
The human adenovirus genome is transported into the nucleus, where viral gene transcription, viral DNA replication, and virion assembly take place. Posttranslational modifications by small ubiquitin-like modifiers (SUMOs) are implicated in the regulation
Sook-Young Sohn, Patrick Hearing
doaj   +1 more source

Presence of adenovirus species C in infiltrating lymphocytes of human sarcoma. [PDF]

PLoS ONE, 2013
Human adenoviruses are known to persist in T-lymphocytes of tonsils, adenoids and intestinal tract. The oncogenic potential of different adenovirus types has been widely studied in rodents, in which adenovirus inoculation can induce multiple tumors such ...
Karin Kosulin, Franziska Hoffmann, Till Sebastian Clauditz, Waldemar Wilczak, Thomas Dobner   +4 more
doaj   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source