Results 81 to 90 of about 2,152,983 (311)

A clinical case of intricate tracheal disease and asthma

Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche, 2017
Context: Asthma is the most common inflammatory disease of the airways in children. The term problematic asthma is used to describe children with chronic symptoms or acute severe exacerbations, or both, not responding to standard asthma therapy.
Ilenia Panasiti, Lucia Caminiti, Andrea Barbalace, Giorgia Pepe, Giuseppe Crisafulli, Giovanni B Pajno, Filippo De Luca   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Psychological and Clinical Challenges in the Management of Type 1 Diabetes during Adolescence: A Narrative Review

Children
Adolescence, a critical period of physical and psychological development, presents unique challenges in type 1 diabetes (T1D) management due to endocrinological changes, reduced therapeutic adherence, and elevated susceptibility to psychological issues ...
Bruno Bombaci, Arianna Torre, Alessandro Longo, Maria Pecoraro, Mattia Papa, Lacrima Sorrenti, Mariarosaria La Rocca, Fortunato Lombardo, Giuseppina Salzano   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Isolation and characterization of mesenchymal stem cells from cultured human pancreatic islets of langerhans [PDF]

, 2006
Replacement of insulin producing β-cells that reside within pancreatic islets represents an almost ideal treatment for patients with diabetes mellitus type 1.
Eberhardt, Michael
core   +1 more source

Digital technology use and adoption in informal entrepreneurship: evidence from Okere District, Ghana

Journal of Innovation and Entrepreneurship
The integration of digital technologies (DT) into informal entrepreneurship (IE) is increasingly recognized as a critical driver of economic productivity, market accessibility and operational efficiency, particularly in developing economies.
Abigail A. Aryeh-Adjei, Kofi Koranteng Adu, Ama Otwiwah Adu-Marfo, Goldman Awuku   +3 more
doaj   +1 more source

A case of severe ketoacidosis as the first clinical manifestation of type 2 diabetes mellitus in a youngster

Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche
Type 2 diabetes (T2D) is a chronic condition caused by insulin resistance and relative insulin deficiency, leading to disrupted glucose homeostasis. Several genetic, behavioral, and socio-economic factors have been recognized as predisposing factors. The
Bruno Bombaci, Fortunato Lombardo, Stefano Passanisi, Sara Aramnejad, Rossella Morello, Mariella Valenzise, Giuseppina Salzano, Malgorzata Gabriela Wasniewska   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source