Optimization of HPLC methods for the development of quality control methods of combined powder formulations with paracetamol, phenylephrine hydrochloride, pheniramine maleate [PDF]
BMC ChemistryOur main goal was to optimize HPLC methods for the determination of a combined powder containing paracetamol, phenylephrine hydrochloride, and pheniramine maleate based on the indicators «Quantitative determination», «Uniformity of dosage units», and «4 ...
Oleksandra Havrylenko +4 more
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Comparative Bioequivalence and Safety Evaluation of Ibuprofen/Phenylephrine Hydrochloride Fixed-Dose Combination Tablets in Healthy Chinese Volunteers. [PDF]
Clin Pharmacol Drug DevThis single‐center, randomized, open‐label bioequivalence program compared two fixed‐dose combination (FDC) tablets containing ibuprofen (200 mg) and phenylephrine hydrochloride (10 mg) from different manufacturers in healthy Chinese adults under fasting
Ye M +8 more
europepmc +3 more sources
Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures [PDF]
Saudi Pharmaceutical Journal, 2017 Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions.
G.G.G. de Oliveira +5 more
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Voltammetric determination of phenylephrine hydrochloride using a multi-walled carbon nanotube-modified carbon paste electrode [PDF]
Royal Society Open Science, 2018 A chemically modified carbon paste electrode (CPE) was designed by mixing graphite and multi-walled carbon nanotubes (MWCNT). The electrochemical behaviour was studied, and the determination method of phenylephrine hydrochloride (PHE) on this sensor was ...
Q. Zhou, H. Y. Zhai, Y. F. Pan
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Capillary zone electrophoresis as a quality assessment tool of paracetamol and phenylephrine hydrochloride in presence of paracetamol impurities. [PDF]
Turk J Chem, 2022 The combination of paracetamol (PAR) and phenylephrine HCl (PHE) is a common pharmaceutical combination intended to manage symptoms of every day cold. Since paracetamol is susceptible to degradation or some manufacturing-related impurities, its stability
Farid JF +3 more
europepmc +2 more sources
An alternative synthesis of (±)-phenylephrine hydrochloride [PDF]
Maejo International Journal of Science and Technology, 2014 This study presents alternative synthetic pathways and reagents for the preparation of racemic phenylephrine hydrochloride. Using m-hydroxybenzaldehyde as starting material, two separate pathways–epoxidation and bromohydrin formation–are
Aphiwat Teerawutgulrag +3 more
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Orbital: The Electronic Journal of ChemistryThe combination of different active substances in drug products is responsible for optimizing therapies and improving patient adherence. However, the development process of these formulations is highly challenging due to differences in the ...
Diana La Luna Bissetti Costa +7 more
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Separation and simultaneous determination of paracetamol, phenylephrine hydrochloride and chlorpheniramine maleate in a commercial tablet by a rapid isocratic HPLC method [PDF]
Human, Health and Halal Metrics, 2020 Background and objective: Pharmaceutical formulations for relief of cold signs usually contain high concentration of acetaminophen and small concentration of phenylephrine hydrochloride and chlorpheniramine maleate.
Afsaneh Nabi +3 more
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Revisiting the impact of phenylephrine hydrochloride on static and dynamic accommodation
Indian Journal of Ophthalmology, 2012 Purpose: Phenylephrine hydrochloride (PHCl), a commonly used mydriatic agent, causes a small but significant deterioration of accommodation. The relative roles of pharmacology and optics in this deterioration, however, remain unascertained.
Samrat Sarkar +2 more
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Spectrophotometric Assay of Phenylephrine Hydrochloride Using 4-Aminoantipyrine and Copper (II) [PDF]
Pakistan Journal of Analytical & Environmental Chemistry, 2010 A new spectrophotometric method is proposed for determination of phenylephrine hydrochloride. The method is based on the coupling of 4-aminoantipyrine (4-AAP) with phenylephrine hydrochloride (PEH) to give a new ligand that reacts with copper (II) in the
Theia'a N. Al-Sabha
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