Results 91 to 100 of about 593,179 (303)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Sense of Self-Agency and Other-Agency Under Social Interaction Contexts

open access: yes
Sense of agency refers to the subjective perception of initiating and controlling one's actions and their consequences within both individual and social contexts. It encompasses not only self-agency, where individuals feel in control of their actions
Huang, Guanhua   +4 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The Many Riches of Human Flourishing: On the Veiled Agent in Veil Narratives [PDF]

open access: yes, 2014
This paper critiques what it calls the parochial conception of agency animating the narrative of the Malayalam writer Khadija Mumthas' novel Barsa (2007) that is anchored in the notion that acts of resistance to relations of domination exhaust the field
Kuzhiyan, Muneer Aram   +1 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Optimal Contracts and Investment in General Human Capital under Common Agency [PDF]

open access: yes
This paper studies contracts and incentives to invest in general human capital under common agency. Both the worker and the employer have too weak investment incentives in equilibrium.
Christos Bilanakos
core  

Comparison of human agency and its components among Farhangiān and State University students [PDF]

open access: yesفصلنامه نوآوری‌های آموزشی, 2019
Nowadays, the process of development of people aged 18 to 25, especially among University students, has become an individual project due to the reduced institutional support, and requires a human agency. On the other hand, the development of human agency
Mohammad Rezā Fathi   +2 more
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

The emancipation of the language learner

open access: yesStudies in Second Language Learning and Teaching, 2012
The general trend in language education over the years has been to ascribe to language learners increasing power and responsibility for their own learning. While this is commendable, the autonomy of learners is still constrained by views of language that
Diane Larsen-Freeman
doaj   +1 more source

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