Results 71 to 80 of about 593,179 (303)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Overcoming restrictive technologies in police call centres: A human agency perspective
, 2008 Call centres in the police force are restrictive information systems which tend to present call operators with constraints that they need to overcome using their experience in order to offer better services to the public.
Spinelli, G +2 more
core
A Neo-Meadian Approach to Human Agency: Relating the Social and the Psychological in the Ontogenesis of Perspective-Coordinating Persons [PDF]
, 2010 How can human agency be reconciled with bio-physical determinism? Starting with a discussion of the long standing debate between determinism and agency, we argue that the seeds of a reconciliation can be found in George Herbert Mead’s ideas concerning ...
Jack Martin +3 more
core +1 more source
“Nothing in Nature Is Naturally a Statue”: William of Ockham on Artifacts
Metaphysics, 2018 Among medieval Aristotelians, William of Ockham defends a minimalist account of artifacts, assigning to statues and houses and beds a unity that is merely spatial or locational rather than metaphysical.
Jack Zupko
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Examining Career Human Agency in Immigrant Professionals in Canada
, 2020 This qualitative study is a secondary data analysis on interviews conducted on immigrant professionals to understand the adjustment and career-related challenges they face as part of the process of resettlement into the Canadian labour force.
Hong, Julie Wai Ling
core +1 more source
Agency of depressed adolescents: embodiment and social representations
International Journal of Qualitative Studies on Health & Well-Being, 2018 Purpose: Major depression is becoming more common among adolescents. Most research into major depression disorder focuses on intrapersonal and interpersonal processes, but the importance of sociocultural factors is less investigated.
Jan De Mol +2 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Co-Constructing Agency in Human-AI Interactions
As AI becomes ever more embedded into daily life and spaces, the discussion of whether AI empowers or disempowers human agency has garnered significant attention.
Gkouskos, Dimitrios, +3 more
core +1 more source