Results 261 to 270 of about 552,451 (291)

Phenytoin binding to human albumin

European Journal of Drug Metabolism and Pharmacokinetics, 1979
Binding of phenytoin to human plasma proteins and to human serum albumin is studied using equilibrium dialysis method at pH 7.4 and 37 degrees C. Phenytoin is mainly bound to albumin, the percentage of bound drug being constant over a wide range of total drug concentrations.
Philippe d'Athis, Michel Lecomte, Jean Paul Tillement, Roland Zini   +3 more
openaire   +3 more sources

Extravascular Albumin in Human Tissues

Clinical Science, 1970
1. Extravascular albumin in human tissue was determined by direct immunochemical analysis. Samples of muscle, skin and intestinal tract obtained at surgery were extracted with a solution of 0· 9% sodium chloride plus 0· 1% desoxycholate and total albumin of the extracts was determined by radial diffusion in agarose plates containing antibody to human ...
George G. Bonorris, Joseph Katz, Sellers Al   +2 more
openaire   +3 more sources

Plurality of human serum albumin

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1972
Abstract Human serum albumin was subjected to ion-exchange chromatography on DEAE Sephadex A-50 and the eluate was subfractionated by gel filtration. Three major and two minor fractions were recognized. The major fractions were: sulfhydryl-rich monomer, sulfhydryl-poor monomer, and the dimer. Of the minor fractions, one was electrophoretically faster
P.K. Shrivastava, K. Zakrzewski, Halina Goch   +2 more
openaire   +3 more sources

A Humanized Mouse Model to Study Human Albumin and Albumin Conjugates Pharmacokinetics

2016
Albumin is a large, highly abundant protein circulating in the blood stream which is regulated and actively recycled via the neonatal Fc receptor (FcRn). In humans this results in serum albumin having an exceptional long half-life of ~21 days. Some time ago it was realized that these intrinsic properties could be harnessed and albumin could be used as ...
Low, Benjamin E, Wiles, Michael V
openaire   +3 more sources

Separation of Human Serum Albumins

Nature, 1960
THE presence of several protein components in human serum albumin was recently demonstrated1–3by two-dimensional zone electrophoresis (filter paper followed by starch gel)4. Their identity with albumin was determined by two-dimensional zone electrophoresis3. The proteins are not related to those described by Knedel4 or by Gitlin et al. 5.
R. Meyer, W. W. Zuelzer, M. D. Poulik
openaire   +3 more sources

Recombinant human serum albumin

Drugs of Today, 2007
Human serum albumin (HSA) is responsible for 80% of the colloid osmotic pressure of plasma (25-33 mmHg). Its main clinical use is in maintaining colloid oncotic pressure and increasing circulating plasma volume with the typical dosage in excess of 10 g per dose.
Chuang, Victor, Otagiri, M.
openaire   +4 more sources

Albumin Máku: a New Variant of Human Serum Albumin

Nature, 1968
AT least six different electrophoretic variants of human serum albumin have been found in man; three migrate more rapidly than normal and three less rapidly1,2. One of these, a rapidly migrating variant, occurs at a frequency of 5–30 per cent in several tribes of North American Indians3.
Napoleon A. Chagnon, Lowell R. Weitkamp
openaire   +3 more sources

The human interferon-albumin interaction: The influence of albumin conformation

Virology, 1975
Abstract When human interferon is chromatographed on bovine serum albumin immobilized via a molecular arm to agarose, there is a selective, transient retention of the interferon. When albumin is defatted prior to immobilization, its interaction with interferon becomes stronger, suggesting that hydrophobic binding is a major force in complex formation.
Jiunn W. Huang, Paul E. Came, William A. Carter, H. Munayyer, Eugene Sulkowski, Gerald H. Silver, Carolyn I. Hejna   +6 more
openaire   +3 more sources

Voltammetric immunoassay of human albumin and goat antiserum to human albumin by cobalt labelling [PDF]

Fresenius' Zeitschrift für analytische Chemie, 1984
Homogeneous and heterogeneous voltammetric immunoassay (VIA) of human albumin and goat antiserum to human albumin were studied by monitoring the current of complexed cobalt and the Brdicka wave at the appropriate potentials as a function of immunochemical reaction using differential pulse polarography. Using homogeneous VIA, concentration levels as low
Ibrahim A. Alam, Gary D. Christian
openaire   +1 more source

Lung uptake of technetium-99m microaggregated human albumin in the rat after treatment with microaggregated human albumin or macroaggregated human albumin

European Journal of Nuclear Medicine, 1978
Marked accumulation in lung and liver of intravenously--injected 99mTc-microaggregated human serum albumin (liver imaging agent) was observed in rats pretreated with the subcutaneous injection of microaggregated or macroaggregated human serum albumin, whereas accumulation of 99mTc-microaggregated human serum albumin was observed only in the liver of ...
Kenichi Kitani, Masahiro Iio, Hideo Yamada, Kazuo Chiba, Shinichiro Kawaguchi, Hajime Murata, Kengo Matsui   +6 more
openaire   +3 more sources