Results 121 to 130 of about 1,355,992 (342)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Human-Leopard Conflict in Girimukti Village, Sukabumi, Indonesia

open access: yes, 2016
Partasasmita R, Shanida SS, Iskandar J, Megantara EN, Husodo T, Malone N. 2016. Human-Leopard Conflict in Girimukti Village, Sukabumi, Indonesia. Biodiversitas 17: 783-790. Populations of leopards continue to decrease over time. This decline is caused by
R. Partasasmita   +6 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Personality and Affiliation in a Cooperative Task for Bottlenose Dolphin (Tursiops truncatus) Dyads [PDF]

open access: yes, 2020
Social species can depend on each other for survival, helping in rearing of young, predator defense, and foraging. Personality dynamics between individuals may influence cooperative behaviors.
Bagley, Kimberly Corinne   +3 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Responsible Regulation of the Religious Slaughter of Animals

open access: yesDerecho Animal, 2019
One of the more intractable issues associated with animal law and ethics concerns responsibly regulating the slaughter of animals according to the requirements of the Jewish religious tradition and some interpretations of the Islamic religious tradition. 
Alex Bruce
doaj   +1 more source

Painted Ferocity: The Social Behaviors of African Wild Dogs, Threats to Survival, and Resulting Conservation Initiatives [PDF]

open access: yes, 2018
African Wild Dogs (Lycaon pictus) are an endangered species of canid from Sub-Saharan Africa. They are very social communal hunters, and are capable of chasing down prey for long stretches of time. Wild dogs benefit a savannah ecosystem by regulating the
Valdes, Alexis
core   +1 more source

Animal geographies III: Relational and political

open access: yesProgress in Human Geography
Animal geography is inherently relational. At its core is curiosity for relations between humans and nonhuman animals. As in other fields, relational approaches are increasingly adopted as conceptual framework and methodology.
Leah M. Gibbs
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

The problem with human equality: Towards a non-exclusive account of the moral value of creatures in the company of Martha Nussbaum [PDF]

open access: yes, 2011
This is that author's pdf version of the book chapter.This book chapter discusses human ...
Clough, David
core  

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