Results 131 to 140 of about 1,355,992 (342)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Ecological Attributes of Carnivore-Livestock Conflict

Frontiers in Ecology and Evolution, 2019
Mitigation of carnivore-human conflict due to domestic animal predation represents an imperative challenge. Although livestock management strategies aimed at reducing predation have recently received attention by wildlife managers and producers, the ...
Carolina S. Ugarte, Darío Moreira-Arce, Darío Moreira-Arce, Darío Moreira-Arce, Javier A. Simonetti, Javier A. Simonetti   +5 more
doaj   +1 more source

Urban conflict management, human‐wild animal interactions, local environmental governance and political participation

Public Administration Review
AbstractLocal authorities today cope with environmental changes. As urbanization advances, the overlap between nature and the world of human beings increases. The resulting new interactions between humans and wild animals have many consequences. The perspectives of public administration and politics regarding this issue remain unexplored.
Itai Beeri, Yaara Sadetzki, Orit Hirsch‐Matsioulas   +2 more
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A bibliometric review of global research on the human-wildlife conflicts

Frontiers in Environmental Science
Human-wildlife conflict (HWC) affects both wildlife sustainability and human wellbeing. Current strategies for human-wildlife conflict are often fragmented and predominantly conservation-focused, lacking the necessary coordination and support from other ...
Azlan Abas, Abdul Hafiz A. Rahman, Tengku Abdul Hadi T. Md Fauzi, Ahmad Hafizuddin M. Yusof   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Human-wildlife conflict and community perceptions towards wildlife conservation in and around a biodiverse National Park, northern Ethiopia

Global Ecology and Conservation
Crop raiding and livestock predation significantly influence the perception of the local community regarding wildlife conservation. The primary aim of this study was to evaluate the scope, characteristics and origin of human-wildlife conflict, as well as
Esayas Embaye Kidane, Seyoum Kiros, Abadi Berhe, Zerihun Girma   +3 more
doaj   +1 more source

The value of wildlife tourism: perspectives from sub-Saharan Africa [PDF]

, 2012
Various authors have used different categories to estimate the value of wildlife, e.g. direct and indirect use values, option values, ethical values, etc. ln this paper, the authors address the value of wildlifebased tourism.
Chardonnet, Philippe, Le Bel, Sébastien
core  

Africa needs to prioritize One Health approaches that focus on the environment, animal health and human health

Nature Medicine, 2021
A. Otu, E. Effa, Clement A Meseko, S. Cadmus, C. Ochu, Rauna Athingo, E. Namisango, D. Ogoina, F. Okonofua, B. Ebenso   +9 more
semanticscholar   +1 more source