Results 231 to 240 of about 12,614,860 (303)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

X- vs. Y-chromosome influences on human behavior: a deep phenotypic comparison of psychopathology in XXY and XYY syndromes. [PDF]

J Neurodev Disord
Schaffer L, Rau S, Larsen IG, Clasen L, Warling A, Whitman ET, Nadig A, McDermott C, Xenophontos A, Wilson K, Blumenthal J, Torres E, Raznahan A.   +12 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Mathematical Assessment of the Role of Human Behavior Changes on SARS-CoV-2 Transmission Dynamics in the United States. [PDF]

Bull Math Biol
Pant B, Safdar S, Santillana M, Gumel AB.   +3 more
europepmc   +1 more source

Interspecies transfer of emotion via chemosignals

, 2018
ALTERISIO, ALESSANDRA, Aria M, Semin G, Scandurra A, D’Aniello B   +4 more
core  

Retraction notice to "Identification and evaluation of educational technology trends from 2004 to 2022: Evidence based on computers in human behavior and horizon report" [Heliyon 10 (2024) e24277]. [PDF]

Heliyon
Liu J, Liu Z, Wang C, Xu Y.
europepmc   +1 more source

Framework restoration on Tang Dynasty garden as a multiple-histories environment: Regions, ecology, architecture, and human behavior. [PDF]

Heliyon
Huang B, Zhang Z, Chen W.
europepmc   +1 more source

Lessons From 3 Longitudinal Sensor-Based Human Behavior Assessment Field Studies and an Approach to Support Stakeholder Management: Content Analysis. [PDF]

J Med Internet Res
Kallio J, Kinnula A, Mäkelä SM, Järvinen S, Räsänen P, Hosio S, Bordallo López M.   +6 more
europepmc   +1 more source

Animate-inanimate object categorization from minimal visual information in the human brain, human behavior, and deep neural networks

Spriet C, Rostami F, Hochmann J, Papeo L.   +3 more
europepmc   +1 more source