Results 231 to 240 of about 11,854,055 (309)

Mechanistic quantification of the effects of genes, environment, and development on human behaviour

González-Forero M, Gómez-Robles A.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

“Regressing Away Common Neural Choice Signals does not make them Artifacts. Comment on Frömer et al (2024, Nature Human Behaviour)”

O’Connell RG, Corbett EA, Parés-Pujolràs E, Feuerriegel D, Kelly SP.   +4 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

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Causal inference on human behaviour

Nature Human Behaviour
Making causal inferences regarding human behaviour is difficult given the complex interplay between countless contributors to behaviour, including factors in the external world and our internal states. We provide a non-technical conceptual overview of challenges and opportunities for causal inference on human behaviour.
Drew H. Bailey, Alexander J. Jung, Adriene M. Beltz, Markus I. Eronen, Christian Gische, Ellen L. Hamaker, Konrad P. Kording, Catherine Lebel, Martin A. Lindquist, Julia Moeller, Adeel Razi, Julia M. Rohrer, Baobao Zhang, Kou Murayama   +13 more
openaire   +5 more sources

Constraints on Human Behaviour

Nature, 1978
This, the authors tells us, is ‘not a work of science; it is a work about science’. Its thesis is that, in the coming period, the social sciences will be transformed by contact with evolutionary biology, in the same way as, in the immediate past, biology has been transformed by contact with chemistry. Human nature, like the nature of ants, hunting dogs
openaire   +1 more source

On ethology and human behaviour

Acta Biotheoretica, 1974
The paper provides a critical discussion of the role ethology may play in the study of human behaviour. The mechanisms of avoidance of consanguineal mating in some animal species and Man are analysed and compared. Aggression and competition are discussed in relation to agonistic courtship, and play behaviour.
openaire   +2 more sources

Fires and Human Behaviour

Psychological aspects of the experience of fires, Canter the concept of panic, Sime a survey of behaviour in fires, Wood fat fires - a domestic hazard, Whittington and Wilson domestic, multiple occupancy and hospital fires, Canter, Breaux and Sime human ...
D. Canter
semanticscholar   +1 more source