Results 91 to 100 of about 237,421 (266)

The Human Behaviour-Change Project Phase 2: Advancing behavioural and social sciences through ontology tools

Wellcome Open Research
Changing behaviour at scale is needed to address the major challenges facing humanity: from preventing and treating disease to tackling the climate crisis. Developing effective interventions to achieve this requires efficient generation and use of scientific evidence.
Susan Michie, Robert West, Janna Hastings, William Hogan, Marta M. Marques, Marie Johnston, Paulina Schenk, Alexander J. Rothman   +7 more
openaire   +2 more sources

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Human Behaviour Change Interventions in Animal Care and Interactive Settings: A Review and Framework for Design and Evaluation. [PDF]

Animals (Basel), 2020
Glanville C, Abraham C, Coleman G.
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Using evidence-based models of human behaviour to reduce endocrine-disrupting chemicals exposure: recommendations for strengthening interventions [version 2; peer review: 2 approved, 3 approved with reservations]

Open Research Europe
Endocrine-disrupting chemicals (EDCs) represent a threat for the ecosystem and human health. Exposure routes include modifiable exposures, such as choice of food or cosmetics but also daily habits such as airing the room.
Annick Bogaerts, Ariane Baye, Roland Devlieger, Alice Collinge, Carmen Freire, Xavier Escoté, Dorota Komar, Barbara Kaiser, Leonie Miserez, Maryse Ledent, Noemi Boqué, Lisa Selma Moussaoui   +11 more
doaj   +1 more source

Factors Influencing Change in Human Behaviour [PDF]

Nature, 1952
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A control system model of capability-opportunity-motivation and behaviour (COM-B) framework for sedentary and physical activity behaviours

Digital Health
Objective Theoretical frameworks are essential for understanding behaviour change, yet their current use is inadequate to capture the complexity of human behaviour such as physical activity.
Reza Daryabeygi-Khotbehsara, David W. Dunstan, Sheikh Mohammed Shariful Islam, Ryan E. Rhodes, Sahar Hojjatinia, Mohamed Abdelrazek, Eric Hekler, Brittany Markides, Ralph Maddison   +8 more
doaj   +1 more source