Results 71 to 80 of about 14,419,622 (241)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Predicting household water use behaviour for improved hygiene practices in internet of things environment via dynamic behaviour intervention model

IET Networks, 2016
Recent advances in Internet of Things (IoT) enabled technologies allow the intelligent sensor systems to effectively and efficiently observe and identify human behaviour in many applications, particularly in energy consumption and healthcare sectors. One
Yang Fu, Wenyan Wu
doaj   +1 more source

Nine challenges in incorporating the dynamics of behaviour in infectious diseases models

Epidemics, 2015
Traditionally, the spread of infectious diseases in human populations has been modelled with static parameters. These parameters, however, can change when individuals change their behaviour.
Sebastian Funk, Shweta Bansal, Chris T. Bauch, Ken T.D. Eames, W. John Edmunds, Alison P. Galvani, Petra Klepac   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Harmony within the new digital paradigm: management of human factor and balance between new and legacy practices

Serbian Journal of Management
Digitalization has become a central topic within societies and organizations, described as a new paradigm or as the fourth industrial revolution. This is a change taking place at many layers, impacting people’s needs, behaviour and expectations.
Camila Calcagno, Jaka Vadnjal
doaj   +1 more source

Current issues and new directions in psychology and health : what happened to behaviour in the decade of behaviour? [PDF]

, 2008
This editorial addresses two key aspects of the investigation of behaviour: the science and the application. On the one hand, researchers and policy makers recognise a need for good scientific evidence about behaviour and behaviour change, but are slow ...
Dixon, D., Marie Johnston, Johnston, Marie, Dixon, Diane, Diane Dixon   +4 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Behaviour change for better health: nutrition, hygiene and sustainability. [PDF]

, 2013
As the global population grows there is a clear challenge to address the needs of consumers, without depleting natural resources and whilst helping to improve nutrition and hygiene to reduce the growth of noncommunicable diseases.
Elmadfa, Ibrahim, Robert J Crawford, Gert W Meijer, Cheryl Hicks, Lowe, C Fergus, Lowe, C. Fergus, Reddy, K Srinath, Myriam Sidibe, Curtis, Valerie, BV Pradeep, Pradeep, BV, Meijer, Gert W., Ibrahim Elmadfa, Marti van Liere, Sidibe, Myriam, Hicks, Cheryl, Lion, Rene, Newson, Rachel S., C Lowe, Crawford, Robert J, van Liere, Marti, Gerda IJ Feunekes, Ricardo Uauy, Meijer, Gert W, Pradeep, B. V., Rene Lion, Uauy, Ricardo, Valerie Curtis, Feunekes, Gerda IJ, K Reddy, Newson, Rachel S, Uauy Dagach-Imbarack, Ricardo, Rachel S Newson, Liere, Marti van, Reddy, K. Srinath, Crawford, Robert J., Feunekes, Gerda   +36 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source