Results 31 to 40 of about 2,100,730 (306)

Human Umbilical Cord Blood Serum–derived α-Secretase

Cell Transplantation, 2018
Alzheimer’s disease (AD) is an age-related disorder that affects cognition. Our previous studies showed that the neuroprotective fragment of amyloid procurer protein (APP) metabolite, soluble APPα (sAPPα), interferes with β-site APP-cleaving enzyme 1 ...
Ahsan Habib, Huayan Hou, Takashi Mori, Jun Tian, Jin Zeng, Shengnuo Fan, Brian Giunta, Paul R. Sanberg, Darrell Sawmiller, Jun Tan   +9 more
doaj   +1 more source

Comparison of serum and plasma as a source of blood extracellular vesicles: Increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions.

PLoS ONE, 2022
Extracellular vesicles (EVs) have attracted much attention as potential diagnostic biomarkers for human diseases. Although both plasma and serum are utilized as a source of blood EVs, it remains unclear whether, how and to what extent the choice of ...
Xiaoman Zhang, Toshihide Takeuchi, Akiko Takeda, Hideki Mochizuki, Yoshitaka Nagai   +4 more
doaj   +1 more source

Genetic regulation of mouse liver metabolite levels. [PDF]

, 2014
We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...
Bennett, Brian J, Che, Nam, Ghazalpour, Anatole, Hagopian, Raffi, He, Aiqing, Kayne, Paul, Kirchgessner, Todd, Lusis, Aldons J, Orozco, Luz, Pan, Calvin, Shih, Diana, Yang, Wen-pin   +11 more
core   +1 more source

Research on Measurement Conditions for Obtaining Significant, Stable, and Repeatable SERS Signal of Human Blood Serum

IEEE Photonics Journal, 2017
The Raman spectra of human blood serum can be used to identify cancer or other diseases; however, obtaining a reliable surface enhanced Raman scattering (SERS) signal of human blood serum is difficult.
Huaizhou Jin, Qipeng Lu, Shangzhong Jin, Zhengbo Song, Yanqiu Zou, Haiquan Ding, Hongzhi Gao, Xingdan Chen   +7 more
doaj   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources

Study of Total Antioxidant Activity of Human Serum Blood in the Pathology of Alcoholism

Molecules, 2013
The total antioxidant activity (TAA) of human serum blood of patients suffering from alcoholism was tested by cathode voltammetry with a model process of oxygen electroreduction. A known spectrophotometrical method was used for comparison. As results the
Evgeniy V. Plotnikov, Mariya V. Bukkel, Elena V. Dorozhko, Wolfgang Linert, Wolfhardt Freinbichler, Elena I. Korotkova, Olesya A. Voronova   +6 more
doaj   +1 more source

Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Pharmacology Research & Perspectives, 2020
A phage‐derived human monoclonal antibody against VEGF‐C was developed as a potential anti‐tumor therapeutic and exhibited fast clearance in preclinical species, with notably faster clearance in serum than in plasma.
Daniela Bumbaca Yadav, Arthur E. Reyes II, Priyanka Gupta, Jean‐Michel Vernes, Y. Gloria Meng, Michelle G. Schweiger, Shannon L. Stainton, Germaine Fuh, Paul J. Fielder, Amrita V. Kamath, Ben‐Quan Shen   +10 more
doaj   +1 more source

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen [PDF]

, 2014
Xenograft rejection of pigs organs with an engineered mutation in the GGTA-1 gene (GTKO) remains a predominantly antibody mediated process which is directed to a variety of non-Gal protein and carbohydrate antigens.
Byrne, GW, Du, Z, Kogelberg, H, McGregor, CG, Stalboerger, P   +4 more
core   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Potential health impacts of heavy metals on HIV-infected population in USA. [PDF]

, 2006
Noninfectious comorbidities such as cardiovascular diseases have become increasingly prevalent and occur earlier in life in persons with HIV infection. Despite the emerging body of literature linking environmental exposures to chronic disease outcomes in
Meliker, Jaymie, Xu, Xiaohui, Hu, Hui, Dailey, Amy B., Kearney, Greg, Talbott, Evelyn O., Cook, Robert L.   +6 more
core   +8 more sources