Results 91 to 100 of about 10,348,104 (306)

AIDS in the human brain [PDF]

Nature, 1986
C H, Fox, M, Cottler-Fox
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Evolutionary modifications in human brain connectivity associated with schizophrenia [PDF]

, 2019
The genetic basis and human-specific character of schizophrenia has led to the hypothesis that human brain evolution may have played a role in the development of the disorder. We examined schizophrenia-related changes in brain connectivity in the context
Rilling, JK, Li, LC, Siemon C de Lange (15242020), Marco P Boks (16276175), van Haren, Neeltje E M, Boks, Marco P., Repple, Jonathan, Koch, Kathrin, Li, Longchuan, de Lange, Siemon C, Rory Pijnenburg (6793328), Jonathan Repple (3350219), van Haren, Neeltje E. M., Neeltje E M van Haren (16276178), Scholtens, Lianne H., Longchuan Li (241491), Repple, J, Lianne H Scholtens (16276172), de Lange, Siemon C., Marco Bozzali (4467988), Pievani, Michela, de Lange, SC, Pievani, M, Rilling, James K, James K Rilling (16278119), Preuss, TM, Kathrin Koch (329273), Pijnenburg, R, van den Heuvel, Martijn P., van Haren, Neeltje E.M., Sommer, Iris E., van den Heuvel, MP, Scholtens, Lianne H.; id_orcid, Koch, K, Bozzali, Marco, Todd M Preuss (16278116), Sommer, IEC, Scholtens, Lianne H, van den Heuvel, Martijn P, Bozzali, M, Cahn, Wiepke, Rilling, James K., Sommer, Iris E, Wiepke Cahn (155467), de Lange, Siemon C.; id_orcid, Cahn, W, Boks, M P, Preuss, Todd M, Scholtens, LH, Michela Pievani (417220), van Haren, Neeltje, Boks, Marco P, Pijnenburg, Rory, Iris E Sommer (16234457), Martijn P van den Heuvel (15242026), Preuss, Todd M.   +55 more
core   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Perisylvian functional connectivity during processing of sentential negation

Frontiers in Psychology, 2011
Every language has the means to reverse the truth value of a sentence by using specific linguistic markers of negation. In the present study we investigated the neural processing costs afforded by the construction of meaning in German sentences ...
Jörg eBahlmann, Jörg eBahlmann, Jutta L Müller, Michiru eMakuuchi, Angela D. Friederici   +4 more
doaj   +1 more source

WEIGHT OF THE HUMAN BRAIN. [PDF]

The Lancet
n ...
openaire   +1 more source

The visualization of the human brain post mortem [PDF]

, 2012
Minimally invasive deep brain neurosurgical interventions require a profound knowledge of the human brain morphology on the micrometer level. Generic brain atlases are based on histology including multiple preparation steps like sectioning and staining ...
Schulz, Georg
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]

, 2013
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A,, Ni, Ruiqing, Marutle, Amelia, Gillberg, P-G, Marutle, A,, Bergfors, A, Nordberg, Agneta, Gillberg, Per-Göran, Bergfors, Assar, Ni, R,   +9 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source