Results 201 to 210 of about 10,348,104 (306)

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

A prognostic human brain network for diffuse midline glioma. [PDF]

Nature
Sidpra J, Lind V, Cohen AL, Schaper FLWVJ, Stone TJ, Grabovska Y, Biswas A, Sudhakar S, Sepulveda F, Peres BS, Veronese G, Alemán-Charlet C, Ogunbiyi O, Shamardani K, Zhao J, Palacin AC, Miller G, Opipari RS, De Vita E, Ridout D, Ferraciolli SF, Lucato LT, Avsenik J, Piccirilli E, Morales-La Madrid A, Muchart J, Ryan ME, Patel R, Haldipur P, Hill CS, Krüger MT, Zrinzo L, Jeelani NUO, Martinez-Barbera JP, Donson AM, Dorris K, Morgan PS, Mackay A, Venkatesh HS, Horn A, Mueller S, Green AL, Mirsky DM, Akram H, Jones C, Aquilina K, Mankad K, Monje M, Jacques TS, Fox MD, Hargrave DR.   +50 more
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Microstructural Correlates of Learning in the Human Brain. [PDF]

Neuroscientist
Lehmann N.
europepmc   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Organization of neuropeptide systems in the human brain. [PDF]

Nat Neurosci
Ceballos EG, Farahani A, Liu ZQ, Milisav F, Hansen JY, Dagher A, Misic B.   +6 more
europepmc   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

An analysis of cerebral amyloid angiopathy based on samples from human brain bank. [PDF]

Front Immunol
Zhang Y, Ye M, Mi S, Zhou Y, Yu Q, Liang J, Wang S, Yang Q, Su Y, Cui H, Ma X, Du J.   +11 more
europepmc   +1 more source

Increased brain-heart coherence and brain connectivity during mindfulness-based stress reduction

, 2021
Gao, J, Sik, HH, Sun, R, Leung, HKH, Wu, WYB   +4 more
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