Results 61 to 70 of about 10,348,104 (306)

Understanding the Human Brain [PDF]

Science, 2011
Like most fields in biology, neuroscience is succumbing to an “epidomic” of data collecting. There are major projects under way to completely characterize the proteomic, metabolomic, genomic, and methylomic signatures for all of the different types of neurons and glial cells in the human brain.
Sydney, Brenner, Terrence J, Sejnowski
openaire   +2 more sources

Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation [PDF]

, 2013
High frequency deep brain stimulation of the thalamus can help ameliorate severe essential tremor. Here we explore how the efficacy, efficiency and selectivity of thalamic deep brain stimulation might be improved in this condition.
Green, Alexander L, Zrinzo, L, Brittain, John-Stuart, Green, Alexander L., Aziz, Tipu, Green, AL, Zrinzo, Ludvic, Little, S, Cagnan, H, Little, Simon, Limousin, P, Fitzgerald, James, Cagnan, Hayrire, Foltynie, Thomas, Hariz, Marwan, Brittain, JS, Limousin, Patricia, Aziz, T, Brown, Peter, Joint, Carole, Fitzgerald, J, Hariz, M, Cagnan, Hayriye, Foltynie, T, Brown, P, Green, Alexander, Joint, C   +26 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Transcranial Stimulation Altered Metabolism of Motor-related brain regions in Depression Patients

, 2022
Transcranial Stimulation Altered Metabolism of Motor-related brain regions in Depression ...
Man, M, Tang, CWA, Lyu, MY, Gao, J, Sik, HH, Hung, BHB, Chung, KF, Thach, TQ, Cheng, JS, Ng, R, Wu, EX, Zhang, Z   +11 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Brain structure and function: a multidisciplinary pipeline to study hominoid brain evolution [PDF]

To decipher the evolution of the hominoid brain and its functions, it is essential to conduct comparative studies in primates, including our closest living relatives. However, strong ethical concerns preclude in vivo neuroimaging of great apes.
Kirilina, Evgeniya, Gräßle, Tobias, Düx, Ariane, Edwards, Luke J, Paquette, Michael, Friederici, Angela D, Anwander, Alfred, Girard-Buttoz, Cédric, Jäger, Carsten, Lipp, Ilona, Kopp, Kathrin S, EBC Consortium,, Wittig, Roman M, Eichner, Cornelius, Jauch, Anna   +14 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Connectivity concordance mapping: a new tool for model-free analysis of fMRI data of the human brain

Frontiers in Systems Neuroscience, 2012
Functional magnetic resonance data acquired in a task-absent condition ("resting state'') require new data analysis techniques that do not depend on an activation model.
Gabriele eLohmann, Smadar eOvadia-Caro, Smadar eOvadia-Caro, Gerhard Jan eJungehülsing, Daniel S Margulies, Daniel S Margulies, Arno eVillringer, Robert eTurner   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Prioritizing spatial accuracy in high-resolution fMRI data using multivariate feature weight mapping

Frontiers in Neuroscience, 2014
Although ultra-high-field fMRI at field strengths of 7T or above provides substantial gains in BOLD contrast-to-noise ratio, when very high-resolution fMRI is required such gains are inevitably reduced.
Johannes eStelzer, Johannes eStelzer, Tilo eBuschmann, Tilo eBuschmann, Gabriele eLohmann, Gabriele eLohmann, Daniel S Margulies, Robert eTrampel, Robert eTurner   +8 more
doaj   +1 more source