Results 11 to 20 of about 1,599,618 (301)

Comparison of tumors with HER2 overexpression versus HER2 amplification in HER2-positive breast cancer patients

BMC Cancer, 2022
Background Human epidermal growth factor receptor 2 (HER2)-positive tumors are defined by protein overexpression (3+) or gene amplification using immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH), respectively.
Yoshiya Horimoto, Yumiko Ishizuka, Yuko Ueki, Toru Higuchi, Atsushi Arakawa, Mitsue Saito   +5 more
doaj   +1 more source

Clinicopathological Examination of Metaplastic Spindle Cell Carcinoma of the Breast: Case Series

Breast Cancer: Basic and Clinical Research, 2021
Background: Spindle cell carcinoma (SpCC) of the breast is a rare histological type, a subtype of metaplastic carcinoma characterized by atypical spindle cell and epithelial carcinoma.
Yumiko Ishizuka, Yoshiya Horimoto, Naotake Yanagisawa, Atsushi Arakawa, Katsuya Nakai, Mitsue Saito   +5 more
doaj   +1 more source

A comprehensive genomic and transcriptomic dataset of triple-negative breast cancers

Scientific Data, 2022
Measurement(s) RNA expression profiling • whole-exome sequencing (WES) • somatic mutations • copy number alterations (CNAs) Technology Type(s) RNA sequencing • DNA sequencing • OncoScan CNV assay Factor Type(s) Intervention or procedure Sample ...
Qingwang Chen, Yaqing Liu, Yuechen Gao, Ruolan Zhang, Wanwan Hou, Zehui Cao, Yi-Zhou Jiang, Yuanting Zheng, Leming Shi, Ding Ma, Jingcheng Yang, Zhi-Ming Shao, Ying Yu   +12 more
doaj   +1 more source

Adaptive immune signature in HER2-positive breast cancer in NCCTG (Alliance) N9831 and NeoALTTO trials

npj Breast Cancer, 2022
Trastuzumab acts in part through the adaptive immune system. Previous studies showed that enrichment of immune-related gene expression was associated with improved outcomes in HER2-positive (HER2+) breast cancer. However, the role of the immune system in
Saranya Chumsri, Zhuo Li, Daniel J. Serie, Nadine Norton, Afshin Mashadi-Hossein, Kathleen Tenner, Heather Ann Brauer, Sarah Warren, Patrick Danaher, Gerardo Colon-Otero, Ann H. Partridge, Lisa A. Carey, Florentine Hilbers, Veerle Van Dooren, Eileen Holmes, Serena Di Cosimo, Olena Werner, Jens Bodo Huober, Amylou C. Dueck, Christos Sotiriou, Cristina Saura, Alvaro Moreno-Aspitia, Keith L. Knutson, Edith A. Perez, E. Aubrey Thompson   +24 more
doaj   +1 more source

Is telomerase reactivation associated with the down-regulatoin of TGFβ receptor-II expression in human breast cancer? [PDF]

, 2003
Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells. TGF beta (
Elkak, AE, Mokbel, K, Newbold, RF, Thomas, V   +3 more
core   +3 more sources

DACH1 suppresses breast cancer as a negative regulator of CD44. [PDF]

, 2017
Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact molecular mechanisms for the anti-tumor roles of DACH1 in breast carcinoma are still lack ...
Kuang, Dong, Pestell, Richard, Wu, Kongming, Xiong, Jing, Xu, Hanxiao, Yu, Shengnan, Yuan, Xun   +6 more
core   +2 more sources

Cerebral hemorrhage due to amyloid angiopathy that was difficult to differentiate from breast cancer metastasis: a case report

Surgical Case Reports, 2021
Background Breast cancer patients are known to develop brain metastasis at a relatively high frequency. However, imaging findings of brain metastases vary, and it is sometimes very difficult to distinguish these from other tumorous lesions and non ...
Toshitaka Uomori, Yoshiya Horimoto, Masashi Takanashi, Ayana Shikanai, Katsuya Nakai, Astushi Arakawa, Mitsue Saito   +6 more
doaj   +1 more source

Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging. [PDF]

, 2018
The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue ...
Adams, Julia, Fisk, John C, Ghazal, Diala, Jessee, Joseph, Johnson, Holly, Karacosta, Loukia G, Koury, Steven, Ludwig, Rachel, Olson, James R, Rittenhouse-Olson, Kate, Roy, Rene, Sajjad, Munawwar, Tati, Swetha, Turner, Bradley   +13 more
core   +2 more sources

Effects of tumor-infiltrating lymphocytes on nonresponse rate of neoadjuvant chemotherapy in patients with invasive breast cancer

Scientific Reports, 2023
High level of tumor-infiltrating lymphocytes (TILs) can predict the rate of total pathological complete remission (tpCR) of breast cancer patients who receive neoadjuvant chemotherapy (NACT).
Xiao-Long Qian, Xiao-Qing Xia, Ya-Qing Li, Yu-Mian Jia, Yuan-Yuan Sun, Yuan-Ming Song, Hui-Qin Xue, Yan-Fei Hao, Jin Wang, Xiao-Zi Wang, Chen-Ying Liu, Xin-Min Zhang, Li-Na Zhang, Xiao-Jing Guo   +13 more
doaj   +1 more source

TG2 as a novel breast cancer prognostic marker promotes cell proliferation and glycolysis by activating the MEK/ERK/LDH pathway

BMC Cancer, 2022
Background Breast cancer (BC) is the most common malignant tumor among women worldwide. Tissue transglutaminase 2 (TG2) has been reported as a major player across several types of cancer.
Dahai Xu, Ning Xu, Liang Sun, Zhaoying Yang, Miao He, Youjun Li   +5 more
doaj   +1 more source