Results 21 to 30 of about 1,599,618 (301)

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]

, 2018
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar, Casimiro, Mathew C., Deng, Shengqiong, DiSante, Gabriele, Dong, Lin, Ertel, Adam, Gormley, Michael, Ju, Xiaoming, Li, Qinchuan, Pestell, Richard G., Pestell, Timothy G., Qiao, Jing, Tozeren, Ayden, Wang, Guangxue, Wang, Min, Yu, Zuoren, Zhao, Qian   +16 more
core   +2 more sources

l-Peptide functionalized dual-responsive nanoparticles for controlled paclitaxel release and enhanced apoptosis in breast cancer cells [PDF]

, 2018
Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by their enhanced permeability and retention effect.
Bremner, David H, Li, Heyu, Niu, Shiwei, Qian, Qianqian, Wang, Haijun, Wu, Jianrong, Wu, Junzi, Zheng, Hong, Zhu, Limin   +8 more
core   +2 more sources

Ring finger protein 126 promotes breast cancer metastasis and serves as a potential target to improve the therapeutic sensitivity of ATR inhibitors

Breast Cancer Research, 2022
Background/aims This study explores the relationship between the E3 ubiquitin ligase Ring finger protein 126 (RNF126) and early breast cancer metastasis and tests the hypothesis that RNF126 determines the efficacy of inhibitors targeting Ataxia ...
You Pan, Yuchao Yang, Rong Huang, Huawei Yang, Qinghua Huang, Yinan Ji, Jingxing Dai, Kun Qiao, Wei Tang, Longgui Xie, Ming Yin, Jun Ouyang, Shipeng Ning, Danke Su   +13 more
doaj   +1 more source

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi, AD Borowsky, AJ Minn, AM Havens, B Brandt, B Qian, Bin-Zhi Qian, BS Nielsen, DR Getts, DR Rhodes, Elizabeth A. Kaiser, F Geissmann, F Geissmann, F Geissmann, FK Swirski, H Saji, HP Gerber, Hui Zhang, Jeffrey W. Pollard, JH Im, Jinghang Zhang, Jiufeng Li, JM Carton, Liam R. Campion, Linda A. Snyder, MD Abramoff, P Stern, P Tsui, RT Palframan, T Ueno, T Valkovic, Takanori Kitamura, Y Huang   +32 more
core   +2 more sources

High platelet-to-lymphocyte ratios in triple-negative breast cancer associates with immunosuppressive status of TILs

Breast Cancer Research, 2022
Background Rating lymphocytes (TILs) are a prognostic marker in breast cancer and high TIL infiltration correlates with better patient outcomes. Meanwhile, parameters involving immune cells in peripheral blood have also been established as prognostic ...
Hiroko Onagi, Yoshiya Horimoto, Asumi Sakaguchi, Daiki Ikarashi, Naotake Yanagisawa, Takayuki Nakayama, Tetsuya Nakatsura, Yumiko Ishizuka, Ritsuko Sasaki, Junichiro Watanabe, Mitsue Saito, Harumi Saeki, Takuo Hayashi, Atsushi Arakawa, Takashi Yao, Shigehisa Kitano   +15 more
doaj   +1 more source

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. [PDF]

, 2018
Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of ...
Blake, Kerrigan, Davis, Ryan Tevia, Driver, Ian, Goga, Andrei, Jabart, Eric, James, Nathan, Kessenbrock, Kai, Khan, Seema A, Kumar, Raj, Lawson, Devon A, Ma, Dennis, Nguyen, Quy H, Pervolarakis, Nicholas, Phung, Anh T, Rock, Jason, Werb, Zena, Willey, Elizabeth   +16 more
core   +1 more source

Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing

Nature Communications, 2020
Chinese breast cancer patients have not been well represented in clinical sequencing studies. Here the authors analyse the mutational landscape of 1,134 Chinese breast cancer patients, finding actionable targets and a higher prevalence of p53 and Hippo ...
Guan-Tian Lang, Yi-Zhou Jiang, Jin-Xiu Shi, Fan Yang, Xiao-Guang Li, Yu-Chen Pei, Chen-Hui Zhang, Ding Ma, Yi Xiao, Peng-Chen Hu, Hai Wang, Yun-Song Yang, Lin-Wei Guo, Xun-Xi Lu, Meng-Zhu Xue, Peng Wang, A-Yong Cao, Hong Ling, Zhong-Hua Wang, Ke-Da Yu, Gen-Hong Di, Da-Qiang Li, Yun-Jin Wang, Ying Yu, Le-Ming Shi, Xin Hu, Wei Huang, Zhi-Ming Shao   +27 more
doaj   +1 more source

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells. [PDF]

, 2017
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed \u27small RNA zipper\u27.
Chen, Yi-Han, Deng, Shengqiong, Fan, Huiming, Li, Wenshu, Liu, Cuicui, Liu, Zhongmin, Lu, Ying, Lü, Jinhui, Meng, Lingyu, Pestell, Richard G., Qiao, Jing, Wang, Guangxue, Yu, Zuoren, Zhang, Chuyi, Zhang, Yuzhen, Zhao, Qian, Zhen, Lixiao   +16 more
core   +2 more sources

The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing

Nature Communications, 2020
Splice isoform switching regulated by the heterogeneous nuclear ribonucleoprotein M (hnRNPM) induces EMT and metastasis. Here, the authors report that AKAP8 is a metastasis suppressor that inhibits the splicing activity of hnRNPM and antagonizes genome ...
Xiaohui Hu, Samuel E. Harvey, Rong Zheng, Jingyi Lyu, Caitlin L. Grzeskowiak, Emily Powell, Helen Piwnica-Worms, Kenneth L. Scott, Chonghui Cheng   +8 more
doaj   +1 more source

A Potent CD1d-binding Glycolipid for iNKT-Cell-based Therapy Against Human Breast Cancer [PDF]

, 2019
Background/Aim: Invariant natural killer T-cells (iNKT) stimulated by CD1d-binding glycolipids have been shown to exert antitumor effects by a number of studies in a mouse model.
Brutkiewicz, Randy R., Liu, Jianyun, Seki, Toshiyuki, Tsuji, Moriya   +3 more
core   +1 more source