Results 31 to 40 of about 801,707 (316)

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Strategies to Promote Empowerment Status of Breast Cancer Women

International Journal of Breast Cancer
Background. As the second leading cause of death in women in the world, breast cancer has several physical and psychological effects. Nowadays, nonclinical approaches such as patient empowerment have been considered by physicians along with clinical care.
Mohammad Amin Bahrami, Shahrzad Tabari, Sedigheh Tahmasebi, Vahid Zangouri, Ramin Ravangard   +4 more
doaj   +1 more source

Vitronectin in human breast carcinomas

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2003
We have analysed the occurrence of the extracellular glycoprotein vitronectin in carcinomas and normal tissue of human breast. Immunohistochemical analysis of carcinomas revealed a strong vitronectin accumulation in extracellular matrix (ECM) around some cancer cell clusters and in the subendothelial area of some blood vessels.
Aaboe, Mads, Offersen, Birgitte Vrou, Christensen, Anni, Andreasen, Peter   +3 more
openaire   +3 more sources

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Characterization of breast cancer tumors in older patients who show de novo resistance to endocrine therapy

Scientific Reports
The standard treatment for hormone receptor-positive breast cancer in good general condition is curative surgery followed by endocrine therapy. However, for older patients, endocrine therapy alone is sometimes chosen instead of curative surgery due to ...
Yumiko Ishizuka, Yoshiya Horimoto, Men Yuan, Yuko Ueki, Hiroko Onagi, Harumi Saeki, Takuo Hayashi, Tsuyoshi Saito, Takahiko Kawate, Takashi Ishikawa, Hidetaka Eguchi, Junichiro Watanabe, Goro Kutomi   +12 more
doaj   +1 more source

Identification of the Collagen Types Essential for Mammalian Breast Acinar Structures

Gels, 2022
Modeling human breast tissue architecture is essential to study the pathophysiological conditions of the breast. We report that normal mammary epithelial cells grown in human breast extracellular matrix (ECM) hydrogel formed acini structurally similar to
Chandler R. Keller, Kelsey F. Ruud, Steve R. Martinez, Weimin Li   +3 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Publisher Correction: EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

Nature Communications, 2018
This Article contains an error in Figure 2. In panel a, the second lane of the western blot should have been labelled ‘siNT’. A correct version of Figure 2a appears in the Author Correction associated with this Article; the error has not been fixed in ...
Deepika Neelakantan, Hengbo Zhou, Michael U. J. Oliphant, Xiaomei Zhang, Lukas M. Simon, David M. Henke, Chad A. Shaw, Meng-Fen Wu, Susan G. Hilsenbeck, Lisa D. White, Michael T. Lewis, Heide L. Ford   +11 more
doaj   +1 more source

Interrogating breast cancer heterogeneity using single and pooled circulating tumor cell analysis

npj Breast Cancer, 2022
Single cell technologies allow the interrogation of tumor heterogeneity, providing insights into tumor evolution and treatment resistance. To better understand whether circulating tumor cells (CTCs) could complement metastatic biopsies for tumor genomic ...
Françoise Rothé, David Venet, Dieter Peeters, Ghizlane Rouas, Mattia Rediti, Dominiek Smeets, Floriane Dupont, Peter Campbell, Diether Lambrechts, Luc Dirix, Christos Sotiriou, Michail Ignatiadis   +11 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source