Results 151 to 160 of about 9,472,885 (361)

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

open access: yesAdvanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu   +20 more
wiley   +1 more source

Soft Bioelectronic Interfaces for Continuous Peripheral Neural Signal Recording and Robust Cross‐Subject Decoding

open access: yesAdvanced Science, EarlyView.
A soft poly (3,4‐ethylenedioxythiophene):poly (styrenesulfonate)‐based electrode enables continuous, high‐quality recording of peripheral nerve activity. A neural network model integrating handcrafted and convolutional neural network‐based features decodes whisker movements with strong generalization, offering insights into peripheral nerve function ...
Liangpeng Chen   +22 more
wiley   +1 more source

Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus

open access: yesAdvanced Science, EarlyView.
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu   +9 more
wiley   +1 more source

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