Results 81 to 90 of about 414,579 (314)

SPANXB1 drives brain metastasis in breast cancer via MMP1 regulation: potential therapeutic insights with metformin

Cell Death Discovery
Cancer-testicular antigens (CTAs) have been considered as potential prognostic biomarkers and therapeutic targets due to their specific expression and roles in tumorigenesis and metastasis.
Qi Wang, Haofeng Wu, Zhaoyi Zhai, Dongliang Fang, Chun Yang, Li Liu, Xiaowei Jia, Baopu Du, Yingqi Lyu, Mingshan Zhang, Tao Lu, Lulu Wang, Yan Gao   +12 more
doaj   +1 more source

Uncertainty and the specificity of human capital [PDF]

Journal of Economic Theory, 2008
L'étude porte sur le choix à opérer entre capital humain général et spécifique. Ce choix implique un arbitrage du fait que le capital humain général, bien que moins productif, peut être facilement transféré d'une entreprise à une autre. Par conséquent, la proportion des travailleurs ayant acquis un capital humain spécifique dépend du degré d ...
Martin Gervais, Igor Livshits, Césaire Meh   +2 more
openaire   +6 more sources

Liquid Crystalline Elastomers in Soft Robotics: Assessing Promise and Limitations

Advanced Robotics Research, EarlyView.
Liquid crystalline elastomers (LCEs) are programmable soft materials that undergo large, anisotropic deformation in response to external stimuli. Their molecular alignment encodes directional actuation in a monolithic structure, making them long‐standing candidates for soft robotic systems.
Justin M. Speregen, Timothy J. White
wiley   +1 more source

From flexibility to fatigue: How job stress mediates the impact of mobile connectivity on burnout and engagement [PDF]

International Journal of Human Capital in Urban Management
BACKGROUND AND OBJECTIVES: The proliferation of smartphones has transformed the modern workplace, blurring boundaries between personal and professional life.
H. Nematollahi, N. Mohammad Esmaeili, S. Naghdi Zarrin   +2 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

The Role of Human Capital to Poverty Reduction : A Case Study of Human Capital in Rural Henan Province, China [PDF]

, 2015
According to the FAO(Oct, 2013) and Asahi Shimbun(July 3, 2015), there are still over 800 million people in the world and over 70 million people in China living with $1.25(or $1) -poverty line-for a day.
韓, 福相, HAN, Bocksang
core   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Human Capital, Aggregation, and Growth [PDF]

The famous Mincer equation regressing log earnings on years of schooling is derived from a linear human capital accumulation equation at the individual level. Even if the cross-sectional Mincer equation holds at the level of individuals, it does not hold
Growiec, Jakub
core   +4 more sources

IT-gestütztes Human Capital Management

HMD Praxis der Wirtschaftsinformatik, 2016
Human Capital Management setzt sich zum Ziel, den Wert des Humankapitals im Unternehmen festzustellen und durch geeignete Masnahmen zu steigern. Vor allem vor dem Hintergrund des demografischen Wandels und dem damit verbundenen Wettbewerb um die besten Spezialisten und Fuhrungskrafte gewinnt diese spezielle Sichtweise des Personalmanagements vermehrt ...
Pilarski, Björn, Decker, Jasmin, Klein, Marco, Tornack, Christian, Schumann, Matthias   +4 more
openaire   +2 more sources

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source