Results 161 to 170 of about 1,235,528 (357)

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

open access: yesAdvanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel   +11 more
wiley   +1 more source

PENGARUH PENGELUARAN PEMERINTAH PUSAT TERHADAP INDEKS PEMBANGUNAN MANUSIA DI INDONESIA [PDF]

open access: yes, 2018
Title: Effect of Government Expenditure on the Human Development Index in IndonesiaName: Muhammad IqbalNIM: 1401101010018Faculty: Economics dan BusinessMajor: Development EconomicsAdvistor : Talbani Farlian, S.E.
Muhammad Iqbal
core  

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

open access: yesAdvanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao   +16 more
wiley   +1 more source

PENGARUH PENDAPATAN ASLI DAERAH, DANA ALOKASI UMUM, DAN DANA ALOKASI KHUSUS TERHADAP INDEKS PEMBANGUNAN MANUSIA DENGAN ALOKASI BELANJA MODAL SEBAGAI VARIABEL INTERVENING (STUDI PADA EKS-KARISIDENAN DI PROVINSI JAWA TENGAH TAHUN 2010-2015) [PDF]

open access: yes, 2017
Human capital is one of the important towards to a better economic development. Aside from being an object, human is one of subject in development goals, in this case measured by human development index.
MIYASTO, Miyasto   +1 more
core  

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

open access: yesAdvanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu   +9 more
wiley   +1 more source

Economic, Institutional & Political Determinants of FDI Growth Effects in Emerging & Developing Countries [PDF]

open access: yes, 2015
This study investigates the role of income levels, using the World Bank income classification, and political development, using EIU Democracy Index scores, in determining the magnitude of FDI growth effects for a panel of 61 emerging and developing ...
Elkomy, Shimaa   +2 more
core  

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

open access: yesAdvanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen   +9 more
wiley   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

open access: yesAdvanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li   +14 more
wiley   +1 more source

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