Results 101 to 110 of about 1,772,181 (298)

Dislocated Boardgames: Design Potentials for Remote Tangible Play

open access: yesMultimodal Technologies and Interaction, 2019
Conventional digital and remote forms of play lack the physicality associated with analog play. Research on the materiality of boardgames has highlighted the inherent material aspects to this analog form of play and how these are relevant for the design ...
Bernhard Maurer, Verena Fuchsberger
doaj   +1 more source

Human-Computer Interaction Using Kinect [PDF]

open access: yes, 2014
Abstrakt Tato bakalářská práce se věnuje ovládání počítače pomocí zařízení Kinect. V práci je popsán princip, jakým zařízení snímá obraz, hloubku obrazu a zvuk.
Knot, Stanislav
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Unobtrusive in-situ measurement of behavior change by deep metric similarity learning of motion patterns

open access: yesFrontiers in Virtual Reality
This paper introduces an unobtrusive in-situ measurement method to measure user behavior changes during arbitrary exposures in XR systems. Here, such behavior changes can be elicited by the avatar’s appearance that the users embody.
Christian Merz   +7 more
doaj   +1 more source

Human-computer interaction as science [PDF]

open access: yes, 2015
Human-computer interaction (HCI) has had a long and troublesome relationship to the role of 'science'. HCI's status as an academic object in terms of coherence and adequacy is often in question---leading to desires for establishing a true scientific ...
Reeves, Stuart
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Speed and Accuracy of Gaze Gestures

open access: yesJournal of Eye Movement Research, 2009
We conducted an experiment where participants carried out six gaze gesture tasks. The gaze paths were analyzed to find out the speed and accuracy of the gaze gestures.
Henna Heikkilä, Kari-Jouko Räihä
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

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