Results 11 to 20 of about 19,354 (212)

Differentiation of Human Embryonic Stem Cells into Cells with Corneal Keratocyte Phenotype [PDF]

, 2013
Corneal transparency depends on a unique extracellular matrix secreted by stromal keratocytes, mesenchymal cells of neural crest lineage. Derivation of keratocytes from human embryonic stem (hES) cells could elucidate the keratocyte developmental pathway
Chan, AA, Davoli, KA, Du, Y, Funderburgh, JL, Funderburgh, ML, Hertsenberg, AJ, Mann, MM, Mich-Basso, JD, Yang, L   +8 more
core   +4 more sources

Selective effects of estradiol on human corneal endothelial cells

bioRxiv, 2023
In Fuchs endothelial corneal dystrophy (FECD), mitochondrial and oxidative stresses in corneal endothelial cells (HCEnCs) contribute to cell demise and disease progression.
Seoyoung Han, C. Mueller, Caitlin Wuebbolt, Sean Kilcullen, Varinda Nayyar, Brayan Calle Gonzalez, A. Mahdavi Fard, Jamie C. Floss, M. Morales, Sangita P. Patel   +9 more
semanticscholar   +1 more source

MiR-302a Regenerates Human Corneal Endothelial Cells against IFN-γ-Induced Cell Death

Cells, 2022
Damage to human corneal endothelial cells (hCECs) leads to bullous keratopathy because these cells cannot be regenerated in vivo. In this study, we investigated the protective role of microRNA (miR)-302a against interferon-γ (IFN-γ)-induced senescence ...
Sehie Park, J. Hwang, Sun‐hee Oh, Y. Shin   +3 more
semanticscholar   +1 more source

Comprehensive Analysis Identified the Circadian Clock and Global Circadian Gene Expression in Human Corneal Endothelial Cells

Investigative Ophthalmology and Visual Science, 2022
Purpose To investigate circadian clock oscillation and circadian global gene expression in cultured human corneal endothelial cells (cHCECs) to elucidate and assess the potential function of circadian regulation in HCECs.
Hiroko Nakai, Yoshiki Tsuchiya, Nobuya Koike, Taiki Asano, Morio Ueno, Yasuhiro Umemura, Yuh Sasawaki, Ryutaro Ono, J. Hamuro, C. Sotozono, K. Yagita   +10 more
semanticscholar   +1 more source

Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect Human Corneal Endothelial Cells from Endoplasmic Reticulum Stress-Mediated Apoptosis

International Journal of Molecular Sciences, 2021
Corneal endothelial dystrophy is a relevant cause of vision loss and corneal transplantation worldwide. In the present study, we analyzed the effect of mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) in an in vitro model of corneal ...
Lola Buono, Simona Scalabrin, Marco De Iuliis, Adele Tanzi, C. Grange, Marta Tapparo, R. Nuzzi, B. Bussolati   +7 more
semanticscholar   +1 more source

Effect of Stem Cell-Derived Extracellular Vesicles on Damaged Human Corneal Endothelial Cells

Stem Cells International, 2021
Purpose Human corneal endothelial cells (HCECs) are essential to visual function; however, since they have limited proliferative capacity in vivo, they are prone to corneal endothelial dysfunction.
R. Nuzzi, Lola Buono, Simona Scalabrin, Marco De Iuliis, B. Bussolati   +4 more
semanticscholar   +1 more source

Construction of 3D in vitro models by bioprinting human pluripotent stem cells: Challenges and opportunities [PDF]

, 2019
Three-dimensional (3D) printing of biological material, or 3D bioprinting, is a rapidly expanding field with interesting applications in tissue engineering and regenerative medicine. Bioprinters use cells and biocompatible materials as an ink (bioink) to
Rosa, Alessandro, Salaris, Federico
core   +1 more source

Identification of Prdm genes in human corneal endothelium [PDF]

, 2017
Corneal endothelial cells (CECs) are essential for maintaining corneal stromal hydration and ensuring its transparency, which is necessary for normal vision. Dysfunction of CECs leads to stromal decompensation, loss of transparency and corneal blindness.
Aldahmesh, Alexandra Chittka, Arndt, Bikoff, Burkitt Wright, Chi, Chittka, Chittka, Chittka, Christiana Georgiou, Derunes, Di Zazzo, Dominic G. O'Donovan, Eghrari, Eppert, Fog, Günesdogan, Hara Susumu, Harper, Hohenauer, Juneja, Jung, Kajimura, Komai, Kostadin Rolev, Liu, Madhavan S. Rajan, Micheal, Micheal, Ohinata, Parekh, Porter, Porter, Qi, Savitsky, Seale, Siegel, Tan, Wu, Zannino, Zhang, Zhang   +41 more
core   +2 more sources

Evaluation of periosteal fixation of lateral rectus and partial VRT for cases of exotropic Duane retraction syndrome

Indian Journal of Ophthalmology, 2014
Purpose: The purpose of this study is to evaluate the lateral rectus periosteal fixation and partial vertical rectus transpositioning (VRT) as treatment modalities to correct exotropic Duane retraction syndrome (Exo-DRS).
Pradeep Sharma, Ruchi Tomer, Vimla Menon, Rohit Saxena, Anudeepa Sharma   +4 more
doaj   +1 more source

Evaluation of moxifloxacin-induced cytotoxicity on human corneal endothelial cells

Scientific Reports, 2021
Moxifloxacin hydrochloride (MXF) is widely used for the prevention of bacterial endophthalmitis after intraocular surgeries. However, the safety issue of intracameral injection of MXF for human corneal endothelial cells (HCECs) is still debatable.
J. Park, Martha A. Kim, R. Chuck, Choul-Yong Park   +3 more
semanticscholar   +1 more source