Results 151 to 160 of about 5,315,351 (390)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
QUALITY – AN ATTRIBUTE OF A TERRITORY’S DEVELOPMENT IN THE CONTEXT OF SUSTAINABLE DEVELOPMENT [PDF]
Sustainability starts from the idea that human activities are dependent on environment and resources. Health, social security and economic stability of society are essential in defining quality of life.
Gabriela BOLOGA, Marin BURTIC?
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Distribution incidence, mortality of tuberculosis and human development index in Iran: estimates from the global burden of disease study 2019. [PDF]
BMC Public Health, 2023 Fallahzadeh H +4 more
europepmc +1 more source
The Human Development Index: A History [PDF]
This article recounts the intellectual history of the UNDP’s Human Development Index. It begins with the early history of welfare economics and follows this field through three successive revolutions in thought, culminating in the theory of human ...
Elizabeth Stanton
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Building a case for incorporating sport as an indicator in human development index. [PDF]
Sport Sci Health, 2023 Som CV.
europepmc +1 more source
Inequality Adjustment Criteria for the Human Development Index [PDF]
Our goal is to analyse the inequality aspects of Human Development Index and to propose a new aggregation function that can adjust it by considering inequality penalisation.
Enrico Casadio Tarabusi, Giulio Guarini
core
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source