Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Human Development and Poverty - a Perspective Across Indian States [PDF]
Statistika: Statistics and Economy Journal, 2012 The ultimate objective of development planning and policies is to increase social welfare and well-being of the society. As income alone is an incomplete measure of well-being of any society, human development attempts to capture quantitative as well as ...
Sonu Madan
doaj
Hypotheses Testing: Capital Flight and Human Development Index in Nigeria
, 2021 Emmanuel Uzoma Makwe +2 more
openalex +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Global incidence and mortality trends of corpus uteri cancer and associations with gross domestic product, human development index, lifestyle, and metabolic risk factors [PDF]
, 2023 Junjie Huang +10 more
openalex +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Changes of the Human Development on Micro-Regional and Settlement Levels
DETUROPE, 2015 The purpose of this paper is to define and estimate the human potential of the settlements in South-Cserehát,, Hungary. The human development index in the classical view can be estimated atmicroregional level with only hard distortions, to which the list
Katalin Lipták
doaj
The Consequences of Inequality: A New Measure of Human Development [PDF]
Marking the 20th anniversary of the Human Development Index (HDI), the United Nations Development Programme (UNDP) has published a revised measure that also accounts for inequality (IHDI).
Guo Xu, Veronika Hümmer
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source