Results 181 to 190 of about 2,748,543 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Toward LLM-aware software effort estimation: a conceptual framework. [PDF]

Front Artif Intell
Alaswad F, Poovammal E, Aljaddouh B.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Measuring Food Safety Culture: A Systematic Review of Questionnaire Dimensions and Validation Practices. [PDF]

Compr Rev Food Sci Food Saf
Wang K, Mirosa M, Hou Y, Bremer P.
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Mapping the political landscape from data traces: Multidimensional opinions of users, politicians and media outlets on X. [PDF]

Data Brief
Vendeville A, Royo-Letelier J, Cassells D, Cointet JP, Crépel M, Faverjon T, Lenoir T, Mazoyer B, Ooghe-Tabanou B, Pournaki A, Yamashita H, Ramaciotti P.   +11 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Psychometric Properties of the Greek Version of the Inpatient Dignity Scale. [PDF]

Healthcare (Basel)
Gkarliaridou M, Matziou V, Zyga S, Fradelos E, Polikandrioti M, Alikari V.   +5 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

General scales unlock AI evaluation with explanatory and predictive power. [PDF]

Nature
Zhou L, Pacchiardi L, Martínez-Plumed F, Collins KM, Moros-Daval Y, Zhang S, Zhao Q, Huang Y, Sun L, Prunty JE, Li Z, Sánchez-García P, Jiang-Chen K, Casares PAM, Zu J, Burden J, Mehrbakhsh B, Stillwell D, Cebrian M, Wang J, Henderson P, Wu ST, Kyllonen PC, Cheke L, Xie X, Hernández-Orallo J.   +25 more
europepmc   +1 more source