Results 151 to 160 of about 148,186 (216)

Benchmarking AI scientists for omics data-driven biological discovery. [PDF]

Bioinformatics
Luo E, Jia J, Xiong Y, Li X, Guo X, Yu B, Hao M, Wei L, Zhang X.   +8 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Insights Into the Mechanisms of Biological Aging That Guide Translational and Clinical Research. [PDF]

Aging Med (Milton)
Fang EF, Nilsen H, Scheibye-Knudsen M, Bohr VA, Kang L.   +4 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Global research synergy: Advancing fundamental Parkinson's research through international collaboration. [PDF]

J Parkinsons Dis
Gutierrez-Arratia J, Saffie-Awad P, Schuh AF, Cornejo-Olivas M.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Exploring experts' views on "Not Parent Expected" discoveries via direct-to-consumer DNA ancestry testing. [PDF]

BMC Med Ethics
Careau J, Feys R, Larmuseau MHD, Drumsta R, Whitley R.   +4 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Printing knowledge in microgravity: PULSE and the education needed for space biomedicine. [PDF]

Exp Physiol
Baatout S, Candotti M, Tabury K, Baselet B, Bailey DM, Moroni L.   +5 more
europepmc   +1 more source