Results 1 to 10 of about 12,648 (111)

Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage [PDF]

Nature Communications, 2023
Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common complication of premature infants. However, the therapy of this type of hemorrhage is limited, and new strategies are needed to reduce hematoma expansion. Here we
Dongyu Li, Shaojun Liu, Tingting Yu, Zhang Liu, Silin Sun, Denis Bragin, Alexander Shirokov, Nikita Navolokin, Olga Bragina, Zhengwu Hu, Jürgen Kurths, Ivan Fedosov, Inna Blokhina, Alexander Dubrovski, Alexander Khorovodov, Andrey Terskov, Maria Tzoy, Oxana Semyachkina-Glushkovskaya, Dan Zhu   +18 more
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Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo [PDF]

Communications Biology
Systemic chemotherapy often affects cells beyond the tumor, raising concerns about their impact on peripheral tissues, including the central nervous system (CNS).
L. Monet Roberts, Jennifer H. Hammel, Peng Jin, Jessica J. Cunningham, Sophia Schumaecker, Skylar Davis, Francesca Azar, Tzu-Yu Alkaid Feng, Maosen Wang, Melanie Rutkowski, Jennifer Munson   +10 more
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Meningeal Lymphatics: An Immune Gateway for the Central Nervous System

Cells, 2021
The recent (re)discovery of the meningeal lymphatic system has opened new theories as to how immune cells traffic and interact with the central nervous system (CNS).
Gabriel A. Tavares, Antoine Louveau
doaj   +3 more sources

Brain Drain for Brain Gain: Potential Applications of Robotic-assisted Lymphatic Microsurgery in the Management of Neurological Disorders [PDF]

Plastic and Reconstructive Surgery, Global Open
Background:. The central nervous system (CNS) was long believed to be devoid of lymphatic drainage. However, the discovery of the glymphatic system and meningeal lymphatics has revolutionized our understanding of cerebrospinal fluid homeostasis and ...
Jennifer A. Watson, MD, Samuel Knoedler, MD, Donata von Reibnitz, MD, Carmen E. Zurfluh, MD, Carlotta Imholz, MMed, Giuseppe Esposito, MD, PhD, Simon J. Schreiner, MD, Epameinondas Gousopoulos, MD, PhD, Aijia Cai, MD, Sedef Kollarik, PhD, Pietro Giovanoli, MD, Christian Baumann, MD, Nicole Lindenblatt, MD   +12 more
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Glymphatics and meningeal lymphatics unlock the brain-immune code [PDF]

Immunity
Min Woo Kim, Jonathan Kipnis
exaly   +3 more sources

Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases

Frontiers in Cellular Neuroscience, 2021
The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF).
Martin Hsu, Collin Laaker, Matyas Sandor, Zsuzsanna Fabry   +3 more
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Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions

Frontiers in Neuroscience, 2023
The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Alexandra Melloni, Alexandra Melloni, Longsha Liu, Longsha Liu, Vivek Kashinath, Reza Abdi, Khalid Shah, Khalid Shah, Khalid Shah   +8 more
doaj   +1 more source

The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans

Frontiers in Physiology, 2022
The human brain functions at the center of a network of systems aimed at providing a structural and immunological layer of protection. The cerebrospinal fluid (CSF) maintains a physiological homeostasis that is of paramount importance to proper ...
Neel H. Mehta, Jonah Sherbansky, Angela R. Kamer, Roxana O. Carare, Tracy Butler, Henry Rusinek, Gloria C. Chiang, Yi Li, Sara Strauss, L. A. Saint-Louis, Neil D. Theise, Richard A. Suss, Kaj Blennow, Michael Kaplitt, Mony J. de Leon   +14 more
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CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges

Frontiers in Pharmacology, 2021
A genuine and functional lymphatic vascular system is found in the meninges that sheath the central nervous system (CNS). This unexpected (re)discovery led to a reevaluation of CNS fluid and solute drainage mechanisms, neuroimmune interactions and the ...
Sofia Pereira das Neves, Nickoleta Delivanoglou, Sandro Da Mesquita   +2 more
doaj   +1 more source

Immune cells as messengers from the CNS to the periphery: the role of the meningeal lymphatic system in immune cell migration from the CNS

Frontiers in Immunology, 2023
In recent decades there has been a large focus on understanding the mechanisms of peripheral immune cell infiltration into the central nervous system (CNS) in neuroinflammatory diseases.
Collin Laaker, Cameron Baenen, Kristóf G. Kovács, Matyas Sandor, Zsuzsanna Fabry   +4 more
doaj   +1 more source