Results 1 to 10 of about 23,235 (301)

Glymphatics and meningeal lymphatics unlock the brain-immune code. [PDF]

Immunity
The central nervous system (CNS) was once perceived as entirely shielded from the immune system, protected behind the blood-brain barrier and thought to lack lymphatic drainage. However, recent evidence has challenged many dogmas in neuroimmunology.
Kim MW, Kipnis J.
europepmc   +5 more sources

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development [PDF]

eLife, 2017
The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals brain lymphatics were only recently discovered, with significant implications for physiology and disease. We examined zebrafish
Max van Lessen, Shannon Shibata-Germanos, Andreas van Impel, Thomas A Hawkins, Jason Rihel, Stefan Schulte-Merker   +5 more
doaj   +3 more sources

Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage [PDF]

Nature Communications, 2023
Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common complication of premature infants. However, the therapy of this type of hemorrhage is limited, and new strategies are needed to reduce hematoma expansion. Here we
Dongyu Li, Shaojun Liu, Tingting Yu, Zhang Liu, Silin Sun, Denis Bragin, Alexander Shirokov, Nikita Navolokin, Olga Bragina, Zhengwu Hu, Jürgen Kurths, Ivan Fedosov, Inna Blokhina, Alexander Dubrovski, Alexander Khorovodov, Andrey Terskov, Maria Tzoy, Oxana Semyachkina-Glushkovskaya, Dan Zhu   +18 more
doaj   +2 more sources

Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo [PDF]

Communications Biology
Systemic chemotherapy often affects cells beyond the tumor, raising concerns about their impact on peripheral tissues, including the central nervous system (CNS).
L. Monet Roberts, Jennifer H. Hammel, Peng Jin, Jessica J. Cunningham, Sophia Schumaecker, Skylar Davis, Francesca Azar, Tzu-Yu Alkaid Feng, Maosen Wang, Melanie Rutkowski, Jennifer Munson   +10 more
doaj   +2 more sources

Antigen-specific immune reactions to ischemic stroke [PDF]

Frontiers in Cellular Neuroscience, 2014
Brain proteins are detected in the CSF and blood of stroke patients and their concentration is related to the extent of brain damage. Antibodies against brain antigens develop after stroke, suggesting a humoral immune response to the brain injury ...
Xabier eUrra, Xabier eUrra, Francesc eMiró, Ángel eChamorro, Ángel eChamorro, Anna M Planas, Anna M Planas   +6 more
doaj   +2 more sources

Brain Drain for Brain Gain: Potential Applications of Robotic-assisted Lymphatic Microsurgery in the Management of Neurological Disorders [PDF]

Plastic and Reconstructive Surgery, Global Open
Background:. The central nervous system (CNS) was long believed to be devoid of lymphatic drainage. However, the discovery of the glymphatic system and meningeal lymphatics has revolutionized our understanding of cerebrospinal fluid homeostasis and ...
Jennifer A. Watson, MD, Samuel Knoedler, MD, Donata von Reibnitz, MD, Carmen E. Zurfluh, MD, Carlotta Imholz, MMed, Giuseppe Esposito, MD, PhD, Simon J. Schreiner, MD, Epameinondas Gousopoulos, MD, PhD, Aijia Cai, MD, Sedef Kollarik, PhD, Pietro Giovanoli, MD, Christian Baumann, MD, Nicole Lindenblatt, MD   +12 more
doaj   +2 more sources

Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases

Frontiers in Cellular Neuroscience, 2021
The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF).
Martin Hsu, Collin Laaker, Matyas Sandor, Zsuzsanna Fabry   +3 more
doaj   +1 more source

Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions

Frontiers in Neuroscience, 2023
The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Alexandra Melloni, Alexandra Melloni, Longsha Liu, Longsha Liu, Vivek Kashinath, Reza Abdi, Khalid Shah, Khalid Shah, Khalid Shah   +8 more
doaj   +1 more source

The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans

Frontiers in Physiology, 2022
The human brain functions at the center of a network of systems aimed at providing a structural and immunological layer of protection. The cerebrospinal fluid (CSF) maintains a physiological homeostasis that is of paramount importance to proper ...
Neel H. Mehta, Jonah Sherbansky, Angela R. Kamer, Roxana O. Carare, Tracy Butler, Henry Rusinek, Gloria C. Chiang, Yi Li, Sara Strauss, L. A. Saint-Louis, Neil D. Theise, Richard A. Suss, Kaj Blennow, Michael Kaplitt, Mony J. de Leon   +14 more
doaj   +1 more source

Progress on Brain and Ocular Lymphatic System

BioMed Research International, 2022
In recent years, 2 major discoveries have modified the traditional understanding of the brain. First, meningeal lymphatic vessels (MLV) were found in the dural sinus, which may absorb and drain cerebrospinal fluid (CSF). Second, the glymphatic system was discovered, composed of para‐arterial CSF influx channel, paravenous interstitial fluid (ISF ...
Yang Xu, Lu Cheng, Lu Yuan, Qianya Yi, Liuyi Xiao, Hui Chen   +5 more
openaire   +3 more sources