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Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage [PDF]
Nature Communications, 2023 Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common complication of premature infants. However, the therapy of this type of hemorrhage is limited, and new strategies are needed to reduce hematoma expansion. Here we
Dongyu Li +18 more
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Lymphatic Drainage of Cerebrospinal Fluid Using Lymph Node Seeker 64Cu‐Labeled Gram‐Negative Bacterial Extracellular Vesicles With Positron Emission Tomography (PET) [PDF]
Journal of Extracellular VesiclesCerebrospinal fluid (CSF) is drained into the systemic lymphatics via paravertebral lymph nodes. Superficial and deep cervical lymph nodes collect CSF in mice, but the exact and quantified routes are unknown.
Kyuwan Kim +11 more
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Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases
Frontiers in Cellular Neuroscience, 2021 The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF).
Martin Hsu +3 more
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Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions
Frontiers in Neuroscience, 2023 The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Alexandra Melloni +8 more
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The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans
Frontiers in Physiology, 2022 The human brain functions at the center of a network of systems aimed at providing a structural and immunological layer of protection. The cerebrospinal fluid (CSF) maintains a physiological homeostasis that is of paramount importance to proper ...
Neel H. Mehta +14 more
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CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges
Frontiers in Pharmacology, 2021 A genuine and functional lymphatic vascular system is found in the meninges that sheath the central nervous system (CNS). This unexpected (re)discovery led to a reevaluation of CNS fluid and solute drainage mechanisms, neuroimmune interactions and the ...
Sofia Pereira das Neves +2 more
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Frontiers in Immunology, 2023 In recent decades there has been a large focus on understanding the mechanisms of peripheral immune cell infiltration into the central nervous system (CNS) in neuroinflammatory diseases.
Collin Laaker +4 more
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Frontiers in Pharmacology, 2023 Background: Fluids, solutes and immune cells have been demonstrated to drain from the brain and surrounding structures to the cervical lymph vessels and nodes in the neck via meningeal lymphatics, nasal lymphatics and/or lymphatic vessels associated with
Thu A. Hoang +4 more
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Established, New and Emerging Concepts in Brain Vascular Development
Frontiers in Physiology, 2021 In this review, we discuss the state of our knowledge as it relates to embryonic brain vascular patterning in model systems zebrafish and mouse. We focus on the origins of endothelial cell and the distinguishing features of brain endothelial cells ...
Ankan Gupta +2 more
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Brain and Behavior, 2023 Background and purpose The discovery of glymphatic function in the human brain has generated interest in waste clearance mechanisms in neurological disorders such as multiple sclerosis (MS). However, noninvasive in vivo functional assessment is currently
Refaat E. Gabr +3 more
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