Results 41 to 50 of about 23,235 (301)

Overview of the meningeal lymphatic vessels in aging and central nervous system disorders

Cell & Bioscience, 2022
In the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even ...
Huimin Jiang, Huimin Wei, Yifan Zhou, Xuechun Xiao, Chen Zhou, Xunming Ji   +5 more
doaj   +1 more source

The role of the lymphatic system in cholesterol transport [PDF]

, 2015
Reverse cholesterol transport (RCT) is the pathway for removal of peripheral tissue cholesterol and involves transport of cholesterol back to liver for excretion, starting from cellular cholesterol efflux facilitated by lipid-free apolipoprotein A1 ...
Andrew Elvington, Gwendalyn J. Randolph, Li-Hao Huang   +2 more
core   +3 more sources

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Breast metastasis of primary colon cancer with micrometastasis in the axillary sentinel node: A metastasis that metastasized?

Diagnostic Pathology, 2011
A case of single breast metastasis from colon adenocarcinoma, with omolateral axillary micrometastasis, is reported with a brief review of the pertinent literature.
Massarut Samuele, Memeo Lorenzo, Canzonieri Vincenzo, Perin Tiziana   +3 more
doaj   +1 more source

Human brain arteriovenous malformations express lymphatic‐associated genes

Annals of Clinical and Translational Neurology, 2014
AbstractObjectiveBrain arteriovenous malformations (AVMs) are devastating, hemorrhage‐prone, cerebrovascular lesions characterized by well‐defined feeding arteries, draining vein(s) and the absence of a capillary bed. The endothelial cells (ECs) that comprise AVMs exhibit a loss of arterial and venous specification.
Shoemaker, Lorelei D, Fuentes, Laurel F, Santiago, Shauna M, Allen, Breanna M, Cook, Douglas J, Steinberg, Gary K, Chang, Steven D   +6 more
openaire   +2 more sources

Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia

Archives of Plastic Surgery
This case report explores the therapeutic potential of lymphovenous bypass (LVB) surgery performed at the neck in neurodegenerative diseases, specifically Alzheimer's disease (AD) dementia.
Qingping Xie, Changsik John Pak, Jingeun Kwon, Sung-Chuan Chao, Joon Pio Hong   +4 more
doaj   +1 more source

Meningeal lymphatic vessels regulate brain tumor drainage and immunity [PDF]

Cell Research, 2020
AbstractRecent studies have shown that meningeal lymphatic vessels (MLVs), which are located both dorsally and basally beneath the skull, provide a route for draining macromolecules and trafficking immune cells from the central nervous system (CNS) into cervical lymph nodes (CLNs), and thus represent a potential therapeutic target for treating ...
Xueting Hu, Qiuping Deng, Lu Ma, Qingqing Li, Yidong Chen, Yuhan Liao, Fan Zhou, Chen Zhang, Linlin Shao, Jun Feng, Tubao He, Weihai Ning, Yan Kong, Yingqing Huo, Aibin He, Bing Liu, Jingjing Zhang, Ralf Adams, Yulong He, Fuchou Tang, Xiuwu Bian, Jincai Luo   +21 more
openaire   +2 more sources

Proteomic and epigenomic markers of sepsis-induced delirium (SID) [PDF]

, 2015
In elderly population sepsis is one of the leading causes of intensive care unit (ICU) admissions in the United States. Sepsis-induced delirium (SID) is the most frequent cause of delirium in ICU (Martin et al., 2010). Together delirium and SID represent
Adonis eSfera, Amy I Price, Carolina eOsorio, Michael eCummings, Roberto eGradini, Roberto eGradini   +5 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The nasal lymphatic route of CSF outflow: implications for neurodegenerative disease diagnosis and monitoring

Animal Cells and Systems
Cerebrospinal fluid (CSF) plays a crucial role in the brain's lymphatics as it traverses the central nervous system (CNS). Its primary function is to facilitate the outward transport of waste. Among the various CSF outflow pathways, the route through the
Jiwon Chae, Mina Choi, Juyoung Choi, Seung-Jun Yoo   +3 more
doaj   +1 more source