Meningeal Lymphatics: An Immune Gateway for the Central Nervous System [PDF]
Cells, 2021 The recent (re)discovery of the meningeal lymphatic system has opened new theories as to how immune cells traffic and interact with the central nervous system (CNS).
Antoine Louveau, Louveau Antoine
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Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions [PDF]
Frontiers in Neuroscience, 2023 The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Khalid Shāh, Reza Abdi, Shāh Khalid
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A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice [PDF]
Nature Communications, 2022 The mechanisms underlying sex differences in response to stress are unclear. Here, the authors show that meningeal lymphatics dysfunction modulates the sex difference in the stress susceptibility to depression- and anxiety-like behaviours in mice.
Hu Zhao, Wei-Jye Lin, Xiaojing Ye
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Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage [PDF]
Nature Communications, 2020 Extravasated erythrocytes in cerebrospinal fluid (CSF) contribute to the pathogenesis of subarachnoid haemorrhage (SAH). Here, the authors show that meningeal lymphatics drain extravasated erythorcytes and that blockage of this drainage aggravates SAH ...
Chinyun Wang +2 more
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Impaired Meningeal Lymphatics and Glymphatic Pathway in Patients with White Matter Hyperintensity [PDF]
Advanced ScienceWhite matter hyperintensity (WMH) represents a critical global medical concern linked to cognitive decline and dementia, yet its underlying mechanisms remain poorly understood.
Min Lou
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Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo [PDF]
Communications BiologySystemic chemotherapy often affects cells beyond the tumor, raising concerns about their impact on peripheral tissues, including the central nervous system (CNS).
L. Monet Roberts +10 more
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Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease [PDF]
Molecular Neurodegeneration, 2023 Alzheimer’s disease (AD) is an aging-related form of dementia associated with the accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the brain.
Shanon Rego +2 more
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Meningeal lymphatics as a therapeutic target for neurodegenerative disorders [PDF]
Translational NeurodegenerationAdvancements in visualization methods have brought the meningeal lymphatic system (MLS) into the spotlight. The meningeal lymphatic vessels (mLVs) play a vital role in draining cerebrospinal fluid and immune cells, acting as a central hub for immune ...
Yijia Feng +6 more
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The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives [PDF]
MedCommThe central nervous system (CNS) maintains homeostasis and immune surveillance through a recently defined brain‐wide clearance network: the glymphatic–lymphatic axis. This system couples the intramural glymphatic pathway, responsible for convective fluid
Hangzhe Sun +8 more
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Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI [PDF]
Fluids and Barriers of the CNS, 2023 The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs).
Jun-Hee Kim +3 more
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