Meningeal Lymphatics: An Immune Gateway for the Central Nervous System [PDF]
Cells, 2021 The recent (re)discovery of the meningeal lymphatic system has opened new theories as to how immune cells traffic and interact with the central nervous system (CNS).
Antoine Louveau, Gabriel A Tavares
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Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions [PDF]
Frontiers in Neuroscience, 2023 The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Alexandra Melloni +8 more
doaj +2 more sources
A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice [PDF]
Nature Communications, 2022 The mechanisms underlying sex differences in response to stress are unclear. Here, the authors show that meningeal lymphatics dysfunction modulates the sex difference in the stress susceptibility to depression- and anxiety-like behaviours in mice.
Weiping Dai +18 more
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Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo [PDF]
Communications BiologySystemic chemotherapy often affects cells beyond the tumor, raising concerns about their impact on peripheral tissues, including the central nervous system (CNS).
L. Monet Roberts +10 more
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Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease [PDF]
Molecular Neurodegeneration, 2023 Alzheimer’s disease (AD) is an aging-related form of dementia associated with the accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the brain.
Shanon Rego +2 more
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Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage [PDF]
Nature Communications, 2020 Extravasated erythrocytes in cerebrospinal fluid (CSF) contribute to the pathogenesis of subarachnoid haemorrhage (SAH). Here, the authors show that meningeal lymphatics drain extravasated erythorcytes and that blockage of this drainage aggravates SAH ...
Jinman Chen +11 more
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Meningeal lymphatics as a therapeutic target for neurodegenerative disorders [PDF]
Translational NeurodegenerationAdvancements in visualization methods have brought the meningeal lymphatic system (MLS) into the spotlight. The meningeal lymphatic vessels (mLVs) play a vital role in draining cerebrospinal fluid and immune cells, acting as a central hub for immune ...
Yijia Feng +6 more
doaj +2 more sources
The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives [PDF]
MedCommThe central nervous system (CNS) maintains homeostasis and immune surveillance through a recently defined brain‐wide clearance network: the glymphatic–lymphatic axis. This system couples the intramural glymphatic pathway, responsible for convective fluid
Hangzhe Sun +8 more
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Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI [PDF]
Fluids and Barriers of the CNS, 2023 The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs).
Jun-Hee Kim +3 more
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Meningeal Lymphatics Drives Macrophage Clearance via CCL2-CCR2 Axis After Cerebral Ischemia [PDF]
Current Issues in Molecular BiologyThe mechanisms underlying meningeal lymphatic vessel (mLV)-mediated immune cell clearance after stroke remain unclear. Using a mouse middle cerebral artery occlusion model, we performed single-cell RNA sequencing to analyze post-ischemic meningeal ...
Jing Wang +3 more
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