Meningeal Lymphatics: An Immune Gateway for the Central Nervous System [PDF]
Cells, 2021 The recent (re)discovery of the meningeal lymphatic system has opened new theories as to how immune cells traffic and interact with the central nervous system (CNS).
Antoine Louveau, Louveau Antoine
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Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage [PDF]
Nature Communications, 2020 Extravasated erythrocytes in cerebrospinal fluid (CSF) contribute to the pathogenesis of subarachnoid haemorrhage (SAH). Here, the authors show that meningeal lymphatics drain extravasated erythorcytes and that blockage of this drainage aggravates SAH ...
Jinman Chen, Linmei Wang, Hao Xu
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Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions [PDF]
Frontiers in Neuroscience, 2023 The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Reza Abdi, Khalid Shāh, Shāh Khalid
exaly +4 more sources
A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice [PDF]
Nature Communications, 2022 The mechanisms underlying sex differences in response to stress are unclear. Here, the authors show that meningeal lymphatics dysfunction modulates the sex difference in the stress susceptibility to depression- and anxiety-like behaviours in mice.
Xin Cheng, Binghuo Wu, Yan Zhang
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Current views on meningeal lymphatics and immunity in aging and Alzheimer's disease. [PDF]
Mol Neurodegener, 2023 Alzheimer’s disease (AD) is an aging-related form of dementia associated with the accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the brain.
Rego S, Sanchez G, Da Mesquita S.
europepmc +3 more sources
Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI. [PDF]
Fluids Barriers CNS, 2023 The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs).
Kim JH, Yoo RE, Choi SH, Park SH.
europepmc +3 more sources
Mechanisms of phototherapy of Alzheimer's disease during sleep and wakefulness: the role of the meningeal lymphatics. [PDF]
Front Optoelectron, 2023 With the increase in the aging population, the global number of people with Alzheimer’s disease (AD) progressively increased worldwide. The situation is aggravated by the fact that there is no the effective pharmacological therapy of AD ...
Oxana SG +16 more
europepmc +3 more sources
Impaired Meningeal Lymphatics and Glymphatic Pathway in Patients with White Matter Hyperintensity [PDF]
Advanced ScienceWhite matter hyperintensity (WMH) represents a critical global medical concern linked to cognitive decline and dementia, yet its underlying mechanisms remain poorly understood.
Min Lou, Kemeng Zhang, Zhongyu Luo
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Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer's disease-associated pathology and cognition in mice. [PDF]
Nat CommunMeningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD).
Wang M +7 more
europepmc +3 more sources
Immune cells as messengers from the CNS to the periphery: the role of the meningeal lymphatic system in immune cell migration from the CNS [PDF]
Frontiers in Immunology, 2023 In recent decades there has been a large focus on understanding the mechanisms of peripheral immune cell infiltration into the central nervous system (CNS) in neuroinflammatory diseases.
Collin Laaker +4 more
doaj +2 more sources