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The Glymphatic System: A Beginner’s Guide [PDF]
Neurochemical Research, 2015 The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central ...
Iben Lundgaard +2 more
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Mapping the Brain’s Glymphatic System [PDF]
BiomedicinesThe glymphatic system is a fluid-transport framework in which cerebrospinal fluid (CSF) enters the brain along perivascular routes, exchanges with interstitial fluid (ISF), and exits toward venous, perineural, and meningeal lymphatic pathways enabling ...
Konstantinos Voumvourakis +2 more
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Glymphatic system and mild traumatic brain injury: a mini review [PDF]
Frontiers in NeuroscienceSince the discovery of the glymphatic system in 2012, research on this brain-wide fluid exchange pathway has focused on understanding its role in different neurological diseases.
Pihla Miettinen +7 more
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The glymphatic system in neurodegenerative diseases and brain tumors: mechanistic insights, biomarker advances, and therapeutic opportunities. [PDF]
Acta Neuropathol CommunDysfunction of the glymphatic system (GS), a brain-wide waste clearance pathway dependent on polarized aquaporin-4 (AQP4) water channels on astrocytic endfeet, is increasingly recognized as a critical mechanism in both neurodegenerative diseases and ...
Jia L +9 more
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The glymphatic system clears amyloid beta and tau from brain to plasma in humans [PDF]
Nature CommunicationsDysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and Alzheimer’s disease (AD). In animal models, glymphatic impairment alone can drive AD pathology. Whether this system clears amyloid beta (Aβ) and tau
Paul Dagum +13 more
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Translational NeurodegenerationThe glymphatic system serves as the brain’s clearance system. It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer’s disease (AD).
Danrui Zhao +11 more
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The Glymphatic System：a New Exploration of Pathological Mechanism in Stroke [PDF]
Zhongguo quanke yixue, 2022 The glymphatic system is a system that promotes the exchange and flow of cerebrospinal fluid (CSF) -interstitial fluid (ISF) to maintain the balance of CSF-ISF, and rid the neuropil of toxic proteinaceous metabolites with astroglial water channel ...
YI Ting, JIN Shuoguo, YIN Haiyan, GAO Ping, ZHU Tianmin
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The role of glymphatic system in neurological diseases - literature review
Journal of Education, Health and Sport, 2023 Introduction: The glymphatic system is the equivalent of the lymphatic system in the brain. This system is responsible for the exchange of metabolism waste products between the cerebrospinal fluid and the interstitial fluid.
Karolina Niekurzak +5 more
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Frontiers in Aging Neuroscience, 2021 Perioperative neurocognitive disorder (PND) frequently occurs in the elderly as a severe postoperative complication and is characterized by a decline in cognitive function that impairs memory, attention, and other cognitive domains.
Xuli Ren +7 more
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The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience
Brain Sciences, 2023 This paper delves into the intricate structure and functionality of the brain’s glymphatic system, bringing forth new dimensions in its neuroscientific understanding.
Alexandru Vlad Ciurea +4 more
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