Results 1 to 10 of about 12,211 (230)
JCI Insight, 2021 Status epilepticus (SE) is a neurological emergency usually accompanied by acute cerebral edema and long-term cognitive impairment, and is characterized by neurodegeneration and aberrant hyperphosphorylated tau protein (p-tau) aggregation.
Kewei Liu +9 more
doaj +1 more source
Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease [PDF]
, 2015 Disturbances in the sleep–wake cycle and circadian rhythms are common symptoms of Alzheimer Disease (AD), and they have generally been considered as late consequences of the neurodegenerative processes.
Holtzman, David M +2 more
core +2 more sources
The Ocular Glymphatic Clearance System [PDF]
, 2019 AbstractDespite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified a novel ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve. Amyloid-β (Aβ) was cleared from the vitreous via a pathway driven by the ocular-cranial pressure difference.
Wang, Xiaowei +14 more
openaire +3 more sources
Journal of NanobiotechnologyThe glymphatic system plays an important role in the transportation of cerebrospinal fluid (CSF) and the clearance of metabolite waste in brain. However, current imaging modalities for studying the glymphatic system are limited.
Bin Sun +4 more
doaj +1 more source
Neural Regeneration ResearchThe excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis of Parkinson’s disease, highlighting the urgent need for innovative therapeutic strategies to promote α-synuclein clearance, particularly given the current lack of ...
Xiaoyue Lian +8 more
doaj +1 more source
Optoacoustic imaging of the glymphatic system
Veins and Lymphatics, 2022 Background: The glymphatic system is a brain waste clearance system mediated via cerebrospinal fluid (CSF) flow,1 with implications for influence on neurodegenerative diseases.2 Most preclinical glymphatic studies employ fluorescence imaging, which provides higher specificity, but a smaller field-of-view (FOV), or magnetic resonance imaging (MRI ...
Sarah Shaykevich +7 more
openaire +2 more sources
Modeling Chronic Traumatic Encephalopathy: The Way Forward for Future Discovery [PDF]
, 2015 Despite the extensive media coverage associated with the diagnosis of chronic traumatic encephalopathy (CTE), our fundamental understanding of the disease pathophysiology remains in its infancy.
Anthony L. Petraglia +9 more
core +2 more sources
Frontiers in PsychiatryThe glymphatic system, a macroscopic waste clearance system in the brain, is crucial for maintaining neural health. It facilitates the exchange of cerebrospinal and interstitial fluid, aiding the clearance of soluble proteins and metabolites and ...
Jannik Prasuhn +13 more
doaj +1 more source
The effects of peripheral and central high insulin on brain insulin signaling and amyloid-β in young and old APP/PS1 mice [PDF]
, 2016 Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in vivo experiments are needed to validate these relationships ...
Caesar, Emily E +9 more
core +2 more sources
The role of the lymphatic system in cholesterol transport [PDF]
, 2015 Reverse cholesterol transport (RCT) is the pathway for removal of peripheral tissue cholesterol and involves transport of cholesterol back to liver for excretion, starting from cellular cholesterol efflux facilitated by lipid-free apolipoprotein A1 ...
Andrew Elvington +2 more
core +3 more sources