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PDGF-B Is Required for Development of the Glymphatic System [PDF]
Cell Reports, 2019 Summary: The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways.
Anne Sofie Munk +14 more
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Glymphatic system: a self-purification circulation in brain [PDF]
Frontiers in Cellular NeuroscienceThe glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for drainage ...
Siying Chen +11 more
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Mapping the Brain’s Glymphatic System [PDF]
BiomedicinesThe glymphatic system is a fluid-transport framework in which cerebrospinal fluid (CSF) enters the brain along perivascular routes, exchanges with interstitial fluid (ISF), and exits toward venous, perineural, and meningeal lymphatic pathways enabling ...
Konstantinos Voumvourakis +2 more
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The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle [PDF]
Neurobiology of DiseaseThe term “glymphatic” emerged roughly a decade ago, marking a pivotal point in neuroscience research. The glymphatic system, a glial-dependent perivascular network distributed throughout the brain, has since become a focal point of investigation.
Yu Cai +7 more
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Neurobiology of DiseaseNeurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitates the movement of ...
Yan-rui Sun +4 more
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Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders
Frontiers in Aging Neuroscience, 2022 The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic ...
Dianjun Zhang +8 more
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The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices
Brain Sciences, 2020 The glymphatic system is a “pseudo-lymphatic” perivascular network distributed throughout the brain, responsible for replenishing as well as cleansing the brain.
Oliver Cameron Reddy +1 more
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Associations between the brain glymphatic system and mitochondrial (dys)function: a systematic review [PDF]
Frontiers in NeuroscienceIntroductionPrevious studies have shown that the proper functioning of both mitochondria and the glymphatic system transporting metabolites are essential for brain health.
Tilda Pihala +7 more
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Glymphatic system and mild traumatic brain injury: a mini review [PDF]
Frontiers in NeuroscienceSince the discovery of the glymphatic system in 2012, research on this brain-wide fluid exchange pathway has focused on understanding its role in different neurological diseases.
Pihla Miettinen +7 more
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The glymphatic system clears amyloid beta and tau from brain to plasma in humans [PDF]
Nature CommunicationsDysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and Alzheimer’s disease (AD). In animal models, glymphatic impairment alone can drive AD pathology. Whether this system clears amyloid beta (Aβ) and tau
Paul Dagum +13 more
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