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PDGF-B Is Required for Development of the Glymphatic System [PDF]
Cell Reports, 2019 Summary: The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways.
Anne Sofie Munk +14 more
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Mapping the Brain’s Glymphatic System [PDF]
BiomedicinesThe glymphatic system is a fluid-transport framework in which cerebrospinal fluid (CSF) enters the brain along perivascular routes, exchanges with interstitial fluid (ISF), and exits toward venous, perineural, and meningeal lymphatic pathways enabling ...
Konstantinos Voumvourakis +2 more
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Glymphatic system: a self-purification circulation in brain [PDF]
Frontiers in Cellular NeuroscienceThe glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for drainage ...
Siying Chen +11 more
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The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices
Brain Sciences, 2020 The glymphatic system is a “pseudo-lymphatic” perivascular network distributed throughout the brain, responsible for replenishing as well as cleansing the brain.
Oliver Cameron Reddy +1 more
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Neurobiology of DiseaseThe term “glymphatic” emerged roughly a decade ago, marking a pivotal point in neuroscience research. The glymphatic system, a glial-dependent perivascular network distributed throughout the brain, has since become a focal point of investigation.
Yu Cai +7 more
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Neurobiology of DiseaseNeurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitates the movement of ...
Yan-rui Sun +4 more
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Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders
Frontiers in Aging Neuroscience, 2022 The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic ...
Dianjun Zhang +8 more
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Development and prospect of treating Alzheimer's disease using the glymphatic system [PDF]
Journal of Alzheimer's Disease ReportsAlzheimer's disease (AD) is a common neurodegenerative disorder with progressive cognitive decline and typical amyloid-β (Aβ) and tau pathologies, whose pathogenesis remains unclear.
Jiajie Gu, Zekai Liu, Jiaxiang Gu
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The Glymphatic System：a New Exploration of Pathological Mechanism in Stroke [PDF]
Zhongguo quanke yixue, 2022 The glymphatic system is a system that promotes the exchange and flow of cerebrospinal fluid (CSF) -interstitial fluid (ISF) to maintain the balance of CSF-ISF, and rid the neuropil of toxic proteinaceous metabolites with astroglial water channel ...
YI Ting, JIN Shuoguo, YIN Haiyan, GAO Ping, ZHU Tianmin
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The glymphatic system clears amyloid beta and tau from brain to plasma in humans [PDF]
Nature CommunicationsDysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and Alzheimer’s disease (AD). In animal models, glymphatic impairment alone can drive AD pathology. Whether this system clears amyloid beta (Aβ) and tau
Paul Dagum +13 more
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