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Mapping the Brain’s Glymphatic System [PDF]
BiomedicinesThe glymphatic system is a fluid-transport framework in which cerebrospinal fluid (CSF) enters the brain along perivascular routes, exchanges with interstitial fluid (ISF), and exits toward venous, perineural, and meningeal lymphatic pathways enabling ...
Konstantinos Voumvourakis +2 more
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The Glymphatic System in Diabetes-Induced Dementia [PDF]
Frontiers in Neurology, 2018 The glymphatic system has emerged as an important player in central nervous system (CNS) diseases, by regulating the vasculature impairment, effectively controlling the clearance of toxic peptides, modulating activity of astrocytes, and being involved in
Young-Kook Kim +4 more
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The glymphatic system clears amyloid beta and tau from brain to plasma in humans [PDF]
Nature CommunicationsDysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and Alzheimer’s disease (AD). In animal models, glymphatic impairment alone can drive AD pathology. Whether this system clears amyloid beta (Aβ) and tau
Paul Dagum +13 more
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Neurobiology of DiseaseNeurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitates the movement of ...
Yan-rui Sun +4 more
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Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer’s disease [PDF]
Translational NeurodegenerationThe glymphatic system serves as the brain’s clearance system. It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer’s disease (AD).
Danrui Zhao +11 more
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The Glymphatic System：a New Exploration of Pathological Mechanism in Stroke [PDF]
Zhongguo quanke yixue, 2022 The glymphatic system is a system that promotes the exchange and flow of cerebrospinal fluid (CSF) -interstitial fluid (ISF) to maintain the balance of CSF-ISF, and rid the neuropil of toxic proteinaceous metabolites with astroglial water channel ...
YI Ting, JIN Shuoguo, YIN Haiyan, GAO Ping, ZHU Tianmin
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Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders
Frontiers in Aging Neuroscience, 2022 The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic ...
Dianjun Zhang +8 more
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The Glymphatic System and Pain [PDF]
Medical Acupuncture, 2020 The glymphatic system is network of perivascular spaces through which cerebrospinal fluid and interstitial fluid can move through the brain, clearing metabolic waste, such as amyloid beta, lactate and more, from the parenchyma. This cleaning system is regulated by sleep and norepinephrine, with increased levels of norepinephrine during wakefulness ...
Goldman, Nanna +3 more
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The role of glymphatic system in neurological diseases - literature review
Journal of Education, Health and Sport, 2023 Introduction: The glymphatic system is the equivalent of the lymphatic system in the brain. This system is responsible for the exchange of metabolism waste products between the cerebrospinal fluid and the interstitial fluid.
Karolina Niekurzak +5 more
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Frontiers in Aging Neuroscience, 2021 Perioperative neurocognitive disorder (PND) frequently occurs in the elderly as a severe postoperative complication and is characterized by a decline in cognitive function that impairs memory, attention, and other cognitive domains.
Xuli Ren +7 more
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