Results 41 to 50 of about 18,116,541 (240)

Glymphatic System Dysfunction and its Associated Factors in Wilson's Disease: A DTI-ALPS Study. [PDF]

Brain Behav
Glymphatic function, assessed by DTI‐ALPS index, was impaired in neurological Wilson's disease compared with hepatic phenotype and controls. Age, AST, and UWDRS‐I score independently predicted dysfunction, linking neurodegeneration, liver injury, and altered glymphatic activity. ABSTRACT Background Wilson's disease (WD) is a genetic disorder of copper (
Zhu L, Wu T, Zhang LJ, Liu QY, Zhang LL, Song B, Zhu YL, Hua L, Zhang L, Li B, Sun Q, Xue BC, Xu Y, Han YZ, Han YS.   +14 more
europepmc   +2 more sources

Influencing factors of glymphatic system during perioperative period

Frontiers in Neuroscience
The glymphatic system is a functional cerebrospinal fluid circulatory system that uses peri-arterial space for inflow of cerebrospinal fluid and peri-venous space for efflux of cerebrospinal fluid from brain parenchyma.
Rui Dong, Rui Dong, Rui Dong, Wenjie Liu, Yuqiang Han, Zimo Wang, Linhao Jiang, Liwei Wang, Xiaoping Gu   +8 more
doaj   +1 more source

The glymphatic system and subarachnoid hemorrhage: disruption and recovery

Exploration of Neuroprotective Therapy, 2022
The glymphatic system, or glial-lymphatic system, is a waste clearance system composed of perivascular channels formed by astrocytes that mediate the clearance of proteins and metabolites from the brain.
Stephan Quintin, Arnav Barpujari, Yusuf Mehkri, Jairo Hernandez, Brandon Lucke-Wold   +4 more
doaj   +1 more source

The Glymphatic System: A Review [PDF]

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery, 2018
AbstractThe brain represents ∼ 2% of the adult body mass; conversely, it is responsible for 20% to 25% of the glucose and 20% of the oxygen consumption, receiving 15% of the cardiac output. This substantial metabolic rate is associated with a significant production of biological debris, which is potentially toxic.
Louise Makarem Oliveira, Eberval Gadelha Figueiredo, Carlos Michel Albuquerque Peres   +2 more
openaire   +2 more sources

Can meditation-based approaches improve the cleansing power of the glymphatic system?

Exploration of Neuroprotective Therapy, 2022
The glymphatic system, first described in 2012, is a brain-wide perivascular network that plays an important role in promoting interstitial metabolic waste removal from the brain.
Peter Wostyn, Piet Goddaer
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Age- and glaucoma-induced changes to the ocular glymphatic system

, 2023
The ocular glymphatic system supports bidirectional fluid transport along the optic nerve, thereby removes metabolic wastes including amyloid-β.
Sun, Qian, Richard T. Libby, Sweeney, Amanda, Shinya Sakurai, Libby, Richard T., Sigurdsson, Björn, Christine Delle, Peter Kusk, Delle, Christine, Maiken Nedergaard, Nedergaard, Maiken, Weiguo Peng, Qian Sun, Kusk, Peter, Björn Sigurdsson, Wang, Xiaowei, Peng, Weiguo, Amanda Sweeney, Plá, Virginia, Ting Du, Giannetto, Michael, Michael Giannetto, Du, Ting, Virginia Plá, Sakurai, Shinya, Xiaowei Wang   +25 more
core   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source