Perivascular Spaces, Glymphatic System and MR
Frontiers in Neurology, 2022 The importance of the perivascular space (PVS) as one of the imaging markers of cerebral small vessel disease (CSVD) has been widely appreciated by the neuroradiologists. The PVS surrounds the small blood vessels in the brain and has a signal consistent with the cerebrospinal fluid (CSF) on MR.
Linya Yu +3 more
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Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. [PDF]
, 2017 The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately ...
Igarashi, Hironaka +3 more
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Astrocytes and neurons communicate via a monocarboxylic acid shuttle [PDF]
, 2020 Since formulation of the Astrocyte-Neuron Lactate Shuttle (ANLS) hypothesis in 1994, the hypothesis has provoked criticism and debate. Our review does not criticise, but rather integrates experimental data characterizing proton-linked monocarboxylate ...
Cottrell, Graeme S., Roosterman, Dirk
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MRI and glymphatic system [PDF]
Stroke and Vascular Neurology, 2019 Glymphatic system is newly discovered pseudolymphatic system in brain and it plays an important role in the removal of interstitial metabolic waste products. We discuss and review the role of glymphatic system in neurological diseases, especially focus on the potential of MRI modelling and its associated challenges to obtain useful new information ...
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MRI-Based Demonstration of the Normal Glymphatic System in a Human Population: A Systematic Review
Frontiers in Neurology, 2022 BackgroundThe glymphatic system has been described as one that facilitates the exchange between the cerebrospinal fluid (CSF) and interstitial fluid, and many recent studies have demonstrated glymphatic flow based on magnetic resonance imaging (MRI).
Min Kyoung Lee +3 more
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Convective infux/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways [PDF]
, 2018 Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the "glymphatic system" that proposes tracers enter the brain along periarterial "spaces" and leave the brain along the walls of veins.
Albargothy, Nazira J. +6 more
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What Is the “Glymphatic System”?
Magnetic Resonance in Medical Sciences, 2023 Although the glymphatic system hypothesis is highly popular, it also lacks certain details. In this paper, an attempt was made to present a more clearly defined hypothesis, which is consistent with the past experiment results. The new hypothesis consists of (1) water flux in the brain parenchyma, (2) water and solutes pathway of the perivascular space,
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Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases [PDF]
, 2016 The lymphatic clearance pathways of the brain are different compared to the other organs of the body and have been the subject of heated debates. Drainage of brain extracellular fluids, particularly interstitial fluid (ISF) and cerebrospinal fluid (CSF),
Aldea, Roxana +7 more
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The Role of Glymphatic System in Alzheimer’s and Parkinson’s Disease Pathogenesis
Biomedicines, 2022 Alzheimer’s disease (AD) is the most common cause of neurodegenerative dementia, whilst Parkinson’s disease (PD) is a neurodegenerative movement disorder.
Francesca R. Buccellato +4 more
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Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation [PDF]
, 2016 Sleep deprivation reduces the dextran radial distribution and 125I-apoE inflow from CSF into brain. A-B) Representative images of cascade blue dextran (CB) in mice on normal sleep cycle (A) and in mice during sleep deprivation (SD) (B).
Achariyar, Thiyagaragan M +12 more
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