Results 31 to 40 of about 9,639 (217)

Dysfunction of the Glymphatic System as a Potential Mechanism of Perioperative Neurocognitive Disorders

Frontiers in Aging Neuroscience, 2021
Perioperative neurocognitive disorder (PND) frequently occurs in the elderly as a severe postoperative complication and is characterized by a decline in cognitive function that impairs memory, attention, and other cognitive domains.
Xuli Ren, Shan Liu, Chuang Lian, Haixia Li, Kai Li, Longyun Li, Guoqing Zhao, Guoqing Zhao   +7 more
doaj   +1 more source

The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience

Brain Sciences, 2023
This paper delves into the intricate structure and functionality of the brain’s glymphatic system, bringing forth new dimensions in its neuroscientific understanding.
Alexandru Vlad Ciurea, Aurel George Mohan, Razvan-Adrian Covache-Busuioc, Horia Petre Costin, Vicentiu Mircea Saceleanu   +4 more
doaj   +1 more source

The glymphatic system: Current understanding and modeling [PDF]

iScience, 2022
We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders ...
Bohr, Tomas, Hjorth, Poul G., Holst, Sebastian C., Hrabětová, Sabina, Kiviniemi, Vesa, Lilius, Tuomas, Lundgaard, Iben, Mardal, Kent-Andre, Martens, Erik A., Mori, Yuki, Nägerl, U. Valentin, Nicholson, Charles, Tannenbaum, Allen, Thomas, John H., Tithof, Jeffrey, Benveniste, Helene, Iliff, Jeffrey J., Kelley, Douglas H., Nedergaard, Maiken   +18 more
openaire   +8 more sources

Glymphatic imaging using MRI [PDF]

, 2020
In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid (CSF) or interstitial fluid (ISF) has been suggested by many studies.
Toshiaki Taoka, Shinji Naganawa, Taoka, Toshiaki, Naganawa, Shinji   +3 more
core   +1 more source

The glymphatic system in Huntington's disease. [PDF]

J Huntingtons Dis
The glymphatic system, a macroscopic waste clearance network in the brain, plays a vital role in maintaining neuronal health and brain homeostasis. Functionally analogous to the lymphatic system in other organs, the term “glymphatic” combines “glial” and “lymphatic.” This system facilitates the exchange of cerebrospinal fluid (CSF) and interstitial ...
Duan W, Zhou Y, Liu H.
europepmc   +4 more sources

Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson’s Disease [PDF]

, 2022
Parkinson’s disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative disease and the most prevalent neurodegenerative disorder after Alzheimer’s disease with a high incidence rate in the elderly population.
Andie Massey, Khoo, Tien K., Boag, Matthew K, Dharah Bispo, Pountney, Dean L, Matthew Boag, Scott-Massey, Andie, Bispo, Dharah P. C. F., Annie Magnier, Bispo, Dharah PCF, Boag, Matthew K., Pountney, Dean L., Khoo, Tien K, Dean Pountney, Magnier, Annie, Tien Khoo   +15 more
core   +1 more source

Age- and glaucoma-induced changes to the ocular glymphatic system [PDF]

, 2023
The ocular glymphatic system supports bidirectional fluid transport along the optic nerve, thereby removes metabolic wastes including amyloid-β.
Sun, Qian, Richard T. Libby, Sweeney, Amanda, Shinya Sakurai, Libby, Richard T., Sigurdsson, Björn, Christine Delle, Peter Kusk, Delle, Christine, Maiken Nedergaard, Nedergaard, Maiken, Weiguo Peng, Qian Sun, Kusk, Peter, Björn Sigurdsson, Wang, Xiaowei, Peng, Weiguo, Amanda Sweeney, Plá, Virginia, Ting Du, Giannetto, Michael, Michael Giannetto, Du, Ting, Virginia Plá, Sakurai, Shinya, Xiaowei Wang   +25 more
core   +1 more source

Peristaltic flow in the glymphatic system [PDF]

Scientific Reports, 2020
AbstractThe flow inside the perivascular space (PVS) is modeled using a first-principles approach in order to investigate how the cerebrospinal fluid (CSF) enters the brain through a permeable layer of glial cells. Lubrication theory is employed to deal with the flow in the thin annular gap of the perivascular space between an impermeable artery and ...
Romano, Francesco, Suresh, Vinod, Galie, Peter A., Grotberg, James B.   +3 more
openaire   +5 more sources

Continuous Theta-Burst Stimulation Promotes Paravascular CSF-Interstitial Fluid Exchange through Regulation of Aquaporin-4 Polarization in APP/PS1 Mice

Mediators of Inflammation, 2022
Amyloid-β (Aβ) deposition plays a crucial role in the occurrence and development of Alzheimer’s disease (AD), and impaired Aβ clearance is the leading cause of Aβ deposition.
Cheng Wu, Tuo Lin, Qian Ding, Ni Zhang, Zi-tong Ou, Gui-yuan Cai, Hong-ying Chen, Jia-yue Xu, Ge Li, Zhong Pei, Guang-qing Xu, Yue Lan   +11 more
doaj   +1 more source

Mapping the Glymphatic Pathway Using Imaging Advances

J, 2023
The glymphatic system is a newly discovered waste-clearing system that is analogous to the lymphatic system in our central nervous system. Furthermore, disruption in the glymphatic system has also been associated with many neurodegenerative disorders (e ...
Rajvi N. Thakkar, Ivelina P. Kioutchoukova, Ian Griffin, Devon T. Foster, Pratiksha Sharma, Eduardo Molina Valero, Brandon Lucke-Wold   +6 more
doaj   +1 more source