Results 31 to 40 of about 12,211 (230)

The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience

Brain Sciences, 2023
This paper delves into the intricate structure and functionality of the brain’s glymphatic system, bringing forth new dimensions in its neuroscientific understanding.
Alexandru Vlad Ciurea, Aurel George Mohan, Razvan-Adrian Covache-Busuioc, Horia Petre Costin, Vicentiu Mircea Saceleanu   +4 more
doaj   +1 more source

The Brain’s Glymphatic System: Current Controversies [PDF]

Trends in Neurosciences, 2020
The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic-lymphatic system in clearance of amyloid-β and other ...
Mestre, Humberto, Mori, Yuki, Nedergaard, Maiken   +2 more
openaire   +4 more sources

The glymphatic system: Current understanding and modeling [PDF]

iScience, 2022
We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders ...
Bohr, Tomas, Hjorth, Poul G., Holst, Sebastian C., Hrabětová, Sabina, Kiviniemi, Vesa, Lilius, Tuomas, Lundgaard, Iben, Mardal, Kent-Andre, Martens, Erik A., Mori, Yuki, Nägerl, U. Valentin, Nicholson, Charles, Tannenbaum, Allen, Thomas, John H., Tithof, Jeffrey, Benveniste, Helene, Iliff, Jeffrey J., Kelley, Douglas H., Nedergaard, Maiken   +18 more
openaire   +8 more sources

Peristaltic flow in the glymphatic system [PDF]

Scientific Reports, 2020
AbstractThe flow inside the perivascular space (PVS) is modeled using a first-principles approach in order to investigate how the cerebrospinal fluid (CSF) enters the brain through a permeable layer of glial cells. Lubrication theory is employed to deal with the flow in the thin annular gap of the perivascular space between an impermeable artery and ...
Romano, Francesco, Suresh, Vinod, Galie, Peter A., Grotberg, James B.   +3 more
openaire   +5 more sources

Continuous Theta-Burst Stimulation Promotes Paravascular CSF-Interstitial Fluid Exchange through Regulation of Aquaporin-4 Polarization in APP/PS1 Mice

Mediators of Inflammation, 2022
Amyloid-β (Aβ) deposition plays a crucial role in the occurrence and development of Alzheimer’s disease (AD), and impaired Aβ clearance is the leading cause of Aβ deposition.
Cheng Wu, Tuo Lin, Qian Ding, Ni Zhang, Zi-tong Ou, Gui-yuan Cai, Hong-ying Chen, Jia-yue Xu, Ge Li, Zhong Pei, Guang-qing Xu, Yue Lan   +11 more
doaj   +1 more source

Mapping the Glymphatic Pathway Using Imaging Advances

J, 2023
The glymphatic system is a newly discovered waste-clearing system that is analogous to the lymphatic system in our central nervous system. Furthermore, disruption in the glymphatic system has also been associated with many neurodegenerative disorders (e ...
Rajvi N. Thakkar, Ivelina P. Kioutchoukova, Ian Griffin, Devon T. Foster, Pratiksha Sharma, Eduardo Molina Valero, Brandon Lucke-Wold   +6 more
doaj   +1 more source

Imaging glymphatic response to glioblastoma

Cancer Imaging, 2023
Background The glymphatic system actively exchanges cerebrospinal fluid (CSF) and interstitial fluid (ISF) to eliminate toxic interstitial waste solutes from the brain parenchyma.
Jasleen Kaur, Guangliang Ding, Li Zhang, Yong Lu, Hao Luo, Lian Li, Edward Boyd, Qingjiang Li, Min Wei, Zhenggang Zhang, Michael Chopp, Quan Jiang   +11 more
doaj   +1 more source

Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow [PDF]

, 2019
We review modeling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering, where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural spiking.
A Destexhe, A Louveau, A R Gardner-Medwin, AJ Smith, AS Thrane, B Frankenhaeuser, B Lu, BJ Tully, BV Safronov, C Nicholson, C Silberstein, CL Lopreore, CS Furman, DD Wang, E Lothman, E Syková, EA Newman, EA Newman, EH Park, ER Kandel, G Cordingley, G Einevoll, G Florence, G Halnes, G Halnes, G Rutkowska, G Ullah, Geir Halnes, Geir Halnes, GG Somjen, GG Somjen, H Kager, H Kager, H Zhang, HD Lux, I Østby, I. Dietzel, J Keyser De, J Pods, J Sibille, J Tong, J Ziburkus, JC Vardakis, JJ Iliff, JONATHAN A. COLES, JS Jung, K Støverud, K. Baber, KC Chen, L Hertz, L Odette, L Xie, L Øyehaug, M Amiry-Moghaddam, M Bai, M Hashido, M Léonetti, M Nedergaard, MA Biot, Matti Hämäläinen, MS Jensen, N Hübel, N Kríz, N Macaulay, N Qian, NN Haj-Yasein, NN Haj-Yasein, P Kofuji, Paul L. Nunez, PM Nanninga, R Enger, RK Orkand, Rune Enger, SB Hladky, T Grisar, Tina Pangršič, Y Zhang   +76 more
core   +2 more sources

Glaucoma: the retina and beyond [PDF]

, 2016
Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy, which is estimated to be responsible for 8.4 million cases of irreversible blindness globally.
Cordeiro, MF, Crawley, L, Davis, BM, Javaid, F, Pahlitzsch, M   +4 more
core   +4 more sources

Brain edema : a valid endpoint for measuring hepatic encephalopathy? [PDF]

, 2016
Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease.
Bémeur, Chantal, Cooper, Arthur J. L., Cudalbu, Cristina, Dam, Gitte, Rose, Christopher, Thrane, Alexander S.   +5 more
core   +1 more source