Results 1 to 10 of about 26,122,743 (292)

Water Channels Aquaporin 4 and -1 Expression in Subependymoma Depends on the Localization of the Tumors. [PDF]

PLoS ONE, 2015
We analyzed aquaporin 4 and -1 expression in subependymomas, benign and slow growing brain tumors WHO grade I. Ten subependymoma cases were investigated, five of the fossa inferior and five of the fossa superior.Using immunohistochemistry, we observed ...
Susan Noell, Petra Fallier-Becker, Andreas F Mack, Maike Hoffmeister, Rudi Beschorner, Rainer Ritz   +5 more
doaj   +2 more sources

Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy

Frontiers in Cellular Neuroscience, 2022
Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms underlying seizure activity have been intensely investigated.
Jenny I. Szu, Devin K. Binder
doaj   +2 more sources

Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4 [PDF]

European Cells & Materials, 2021
The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechanical loading. Changes in extracellular osmolality result in cell volume alterations, responsiveness to such changes is essential for cellular homeostasis ...
JW Snuggs, RAD Bunning, CL Le Maitre
doaj   +1 more source

α-Actinin 4 Links Vasopressin Short-Term and Long-Term Regulation of Aquaporin-2 in Kidney Collecting Duct Cells

Frontiers in Physiology, 2021
Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho, Hsiu-Hui Yang, Shih-Han Su, Ai-Hsin Yeh, Ming-Jiun Yu   +4 more
doaj   +1 more source

Ravulizumab in Aquaporin‐4–Positive Neuromyelitis Optica Spectrum Disorder

Annals of Neurology, 2023
CHAMPION‐NMOSD (NCT04201262) is a phase 3, open‐label, externally controlled interventional study evaluating the efficacy and safety of the terminal complement inhibitor ravulizumab in adult patients with anti–aquaporin‐4 antibody–positive (AQP4 ...
S. Pittock, M. Barnett, J. Bennett, A. Berthele, J. de Sèze, M. Levy, I. Nakashima, C. Oreja-Guevara, Jacqueline Palace, F. Paul, C. Pozzilli, M. Yountz, K. Allen, Y. Mashhoon, H. Kim   +14 more
semanticscholar   +1 more source

Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders.

Neurobiology of Disease, 2023
The clearance function is essential for maintaining brain tissue homeostasis, and the glymphatic system is the main pathway for removing brain interstitial solutes.
Shasha Peng, Jia-Chen Liu, Chuntian Liang, Lijun Yang, Gaiqing Wang   +4 more
semanticscholar   +1 more source

Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson's disease.

Journal of Advanced Research, 2023
INTRODUCTION The glymphatic system offers a perivascular pathway for the clearance of pathological proteins and metabolites to optimize neurological functions.
Xiao-Li Si, Shao-bing Dai, Yi Fang, Jiahui Tang, Zhi-Yun Wang, Yao-nian Li, Zhe Song, Ying Chen, Yi Liu, Guohua Zhao, Baorong Zhang, Jiali Pu   +11 more
semanticscholar   +1 more source

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

Alzheimer's Research & Therapy, 2022
Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of Aβ plaques that characterize Alzheimer’s disease (AD). Aβ is cleared in part by the glymphatic system, a brain-wide network of perivascular pathways that supports ...
Matthew J. Simon, M. Wang, O. Ismail, Molly Braun, Abigail G. Schindler, Jesica Reemmer, Zhongya Wang, Mariya A Haveliwala, Ryan O’Boyle, Warren Han, Natalie E. Roese, M. Grafe, R. Woltjer, D. Boison, Jeffrey J. Iliff   +14 more
semanticscholar   +1 more source

The effect of aquaporin-4 mis-localization on Aβ deposition in mice.

Neurobiology of Disease, 2023
The reduced clearance of amyloid-β (Aβ) is thought to contribute to the development of the pathology associated with Alzheimer's disease (AD), which is characterized by the deposition of Aβ plaques.
Taylor Pedersen, Samantha A. Keil, Warren Han, M. Wang, J. Iliff   +4 more
semanticscholar   +1 more source

Aquaporin 4 is differentially increased and dislocated in association with tau and amyloid-beta.

Life Science, 2023
AIMS Neurovascular-glymphatic dysfunction plays an important role in Alzheimer's disease and has been analysed mainly in relation to amyloid-beta (Aβ) pathology.
Vasil Kecheliev, Leo Boss, Upasana Maheshwari, U. Konietzko, Annika Keller, D. Razansky, R. Nitsch, J. Klohs, R. Ni   +8 more
semanticscholar   +1 more source