Results 11 to 20 of about 38,738 (164)

Skull diploë is rich in aquaporin-4 [PDF]

Heliyon, 2020
Aquaporin-4 (AQP4) is a water conducting membrane integral protein channel which is widely expressed in the astrocyte system of the brain. During the development of the AQP4 positron emission tomography (PET) imaging agent [11C]TGN-020 (N-(1,3,4 ...
Yuji Suzuki, Hiroki Kitaura, Yukimi Nakamura, Akiyoshi Kakita, Vincent J. Huber, Nicholas Capozzoli, Ingrid L. Kwee, Tsutomu Nakada   +7 more
doaj   +3 more sources

Aquaporin-4 and Parkinson’s Disease [PDF]

International Journal of Molecular Sciences
The water-selective channel aquaporin-4 (AQP4) is implicated in water homeostasis and the functioning of the glymphatic system, which eliminates various metabolites from the brain tissue, including amyloidogenic proteins. Misfolding of the α-synuclein protein and its post-translational modifications play a crucial role in the development of Parkinson’s
Ksenia V. Lapshina, Irina V. Ekimova
openaire   +3 more sources

Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica.

PLoS Medicine, 2007
BackgroundNeuromyelitis optica (NMO) is a demyelinating disease of the central nervous system (CNS) of putative autoimmune aetiology. Early discrimination between multiple sclerosis (MS) and NMO is important, as optimum treatment for both diseases may ...
Friedemann Paul, Sven Jarius, Orhan Aktas, Martin Bluthner, Oliver Bauer, Heribert Appelhans, Diego Franciotta, Roberto Bergamaschi, Edward Littleton, Jacqueline Palace, Hans-Peter Seelig, Reinhard Hohlfeld, Angela Vincent, Frauke Zipp   +13 more
doaj   +5 more sources

Co-occurrence of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and hepatocellular carcinoma: A case report [PDF]

Journal of International Medical Research
Neuromyelitis optica spectrum disorder is a rare, relapsing autoimmune disease in which the immune system attacks the central nervous system, primarily the optic nerves and spinal cord.
Cheng Li, Weijing Liao, Di Long
doaj   +2 more sources

Aquaporin-4 and Cognitive Disorders

Aging and disease, 2022
Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral part of the glymphatic system that cannot be ignored. The CNS has the glymphatic system instead of the conventional lymphatic system.
Wang, Yifan, Huang, Chuyi, Guo, Qihao, Chu, Heling   +3 more
openaire   +2 more sources

Aquaporin-4 autoimmunity [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2015
Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes. The classic clinical manifestations of NMO are optic neuritis and longitudinally extensive transverse myelitis.
Zekeridou, Anastasia, Lennon, Vanda A.
openaire   +2 more sources

Aquaporin 4 as a NH3 Channel [PDF]

Journal of Biological Chemistry, 2016
Ammonia is a biologically potent molecule, and the regulation of ammonia levels in the mammalian body is, therefore, strictly controlled. The molecular paths of ammonia permeation across plasma membranes remain ill-defined, but the structural similarity of water and NH3 has pointed to the aquaporins as putative NH3-permeable pores. Accordingly, a range
Assentoft, Mette, Kaptan, Shreyas, Schneider, Hans-Peter, Deitmer, Joachim W, de Groot, Bert L, MacAulay, Nanna   +5 more
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Aquaporin-4 and brain edema [PDF]

Pediatric Nephrology, 2007
Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood. This distribution suggests that AQP4 controls water fluxes into and out of the brain parenchyma.
Papadopoulos, MC, Verkman, AS
openaire   +2 more sources

Aquaporin-4 and Cerebrovascular Diseases [PDF]

International Journal of Molecular Sciences, 2016
Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema.
Chu, Heling, Huang, Chuyi, Ding, Hongyan, Dong, Jing, Gao, Zidan, Yang, Xiaobo, Tang, Yuping, Dong, Qiang   +7 more
openaire   +2 more sources

Aquaporin 4 and neuromyelitis optica [PDF]

The Lancet Neurology, 2012
Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) and the evidence that AQP4-IgG is involved in the development of neuromyelitis optica revolutionised our understanding of the disease.
Marios C, Papadopoulos, A S, Verkman
openaire   +2 more sources