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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on AQP4 (aquaporin 4), with data on DNA, on the protein encoded, and where the gene is implicated.
RIBATTI, Domenico, NICO, Beatrice
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Aquaporin-4 expression in the human choroid plexus [PDF]
Cellular and Molecular Life Sciences, 2021 Abstract The choroid plexus (CP) consists of specialized ependymal cells and underlying blood vessels and stroma producing the bulk of the cerebrospinal fluid (CSF). CP epithelial cells are considered the site of the internal blood-cerebrospinal fluid barrier, show epithelial characteristics (basal lamina, tight junctions), and ...
Felix Deffner +7 more
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Rinsho Shinkeigaku, 2008 In human body, there are thirteen water channels but their expression patterns are tissue specific. Aquaporin-4 (AQP4) is a predominantly expressed water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder, and mesial temporal lobe epilepsy.
Tani, Kazutoshi +2 more
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Neuromyelitis optica spectrum disorders with an inverted V sign on spinal cord magnetic resonance imaging: antiaquaporin-4 antibody and functional vitamin B12 deficiency [PDF]
Journal of Medicine and Life Science, 2022 Several studies have reported a possible link between antiaquaporin- 4 antibody and vitamin B12 deficiency in neuromyelitis optica spectrum disorder (NMOSD).
Sung Jo Bang +4 more
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Aquaporin-4 gene silencing protects injured neurons after early cerebral infarction
Neural Regeneration Research, 2015 Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cellular edema after early cerebral infarction.
Zhan-ping He, Hong Lu
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Genetic deletion of laminin isoforms β2 and γ3 induces a reduction in Kir4.1 and aquaporin-4 expression and function in the retina. [PDF]
PLoS ONE, 2011 Glial cells such as retinal Müller glial cells are involved in potassium ion and water homeostasis of the neural tissue. In these cells, inwardly rectifying potassium (Kir) channels and aquaporin-4 water channels play an important role in the process of ...
Petra G Hirrlinger +8 more
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Evaluation of aquaporin‐4 antibody assays [PDF]
Clinical and Experimental Neuroimmunology, 2014 AbstractAquaporin‐4 (AQP4) is a water channel protein that is most highly, but not exclusively, expressed in the central nervous system. In 2005 AQP4 was shown to be the antigenic target of neuromyelitis optica‐immunoglobulin G (NMO‐IgG, or AQP4‐IgG), an antibody found specifically in patients with NMO and in formes frustes of NMO, such as ...
Patrick J, Waters +5 more
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Aquaporin-4 expression in distal myopathy with rimmed vacuoles
BMC Neurology, 2012 Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles.
Hoshi Akihiko +5 more
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Aquaporin 4 and its Relationship with Brain Astrocytomas – Literature Review
Brazilian Neurosurgery, 2023 Background Aquaporins (AQPs) are a family of membrane proteins that regulate the osmotic permeability of the plasma membrane. There are described in the literature a total of 13 types of Aquaporins in mammals, each with different places of expression. In
Raphael Vinícius Gonzaga Vieira +4 more
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Journal of Medical Case Reports, 2019 Background Neuromyelitis optica spectrum disorders are severe autoimmune inflammatory diseases of the central nervous system associated with the presence of immunoglobulin G antibodies against the water channel protein aquaporin-4.
Susanne Bejerot +6 more
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