Results 21 to 30 of about 26,122,743 (292)
Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica.
PLoS Medicine, 2007 BackgroundNeuromyelitis optica (NMO) is a demyelinating disease of the central nervous system (CNS) of putative autoimmune aetiology. Early discrimination between multiple sclerosis (MS) and NMO is important, as optimum treatment for both diseases may ...
Friedemann Paul +13 more
doaj +5 more sources
Aquaporin‐4 Overexpression in Rat ALS Model [PDF]
The Anatomical Record, 2008 AbstractOnset of motoneuron death characterizing amyotrophic lateral sclerosis (ALS) is closely linked to modified astrocytic and glial environments. Here, we show that in the spinal cord from transgenic rat overexpressing mutated human SOD1, aquaporin‐4 mRNA and protein are specifically overexpressed in the gray matter at end stage of disease ...
Nicaise, Charles +6 more
openaire +5 more sources
Aquaporin-4 autoimmunity [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes. The classic clinical manifestations of NMO are optic neuritis and longitudinally extensive transverse myelitis.
Zekeridou, Anastasia, Lennon, Vanda A.
openaire +2 more sources
Aquaporin 4 as a NH3 Channel [PDF]
Journal of Biological Chemistry, 2016 Ammonia is a biologically potent molecule, and the regulation of ammonia levels in the mammalian body is, therefore, strictly controlled. The molecular paths of ammonia permeation across plasma membranes remain ill-defined, but the structural similarity of water and NH3 has pointed to the aquaporins as putative NH3-permeable pores. Accordingly, a range
Assentoft, Mette +5 more
openaire +5 more sources
Alterations in Aquaporin-4-IgG Serostatus in 986 Patients: A Laboratory-Based Longitudinal Analysis
Annals of Neurology, 2023 This study was undertaken to investigate factors associated with aquaporin‐4 (AQP4)‐IgG serostatus change using a large serological database.
M. Majed +14 more
semanticscholar +1 more source
Annals of Neurology, 2023 To investigate aquaporin‐4 antibody (AQP4‐IgG) dynamics and relapse risk in patients with seropositive neuromyelitis optica spectrum disorder treated with immunosuppressants.
H. Yin +9 more
semanticscholar +1 more source
bioRxiv, 2022 The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately establishing directional clearance of interstitial solutes.
R. Gomolka +10 more
semanticscholar +1 more source
Aquaporin-4 and Cerebrovascular Diseases [PDF]
International Journal of Molecular Sciences, 2016 Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema.
Chu, Heling +7 more
openaire +2 more sources
Aquaporin-4 and brain edema [PDF]
Pediatric Nephrology, 2007 Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood. This distribution suggests that AQP4 controls water fluxes into and out of the brain parenchyma.
Papadopoulos, MC, Verkman, AS
openaire +2 more sources
Mechanisms of aquaporin‐4 vesicular trafficking in mammalian cells
Journal of Neurochemistry, 2023 The aquaporin‐4 (AQP4) water channel is abundantly expressed in the glial cells of the central nervous system and facilitates brain swelling following diverse insults, such as traumatic injury or stroke.
A. Markou +6 more
semanticscholar +1 more source