Results 21 to 30 of about 99,139,021 (297)
Aquaporin-4 autoimmunity [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes. The classic clinical manifestations of NMO are optic neuritis and longitudinally extensive transverse myelitis.
Zekeridou, Anastasia, Lennon, Vanda A.
openaire +2 more sources
Aquaporin 4 as a NH3 Channel [PDF]
Journal of Biological Chemistry, 2016 Ammonia is a biologically potent molecule, and the regulation of ammonia levels in the mammalian body is, therefore, strictly controlled. The molecular paths of ammonia permeation across plasma membranes remain ill-defined, but the structural similarity of water and NH3 has pointed to the aquaporins as putative NH3-permeable pores. Accordingly, a range
Assentoft, Mette +5 more
openaire +5 more sources
Aquaporin-4 and brain edema [PDF]
Pediatric Nephrology, 2007 Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood. This distribution suggests that AQP4 controls water fluxes into and out of the brain parenchyma.
Papadopoulos, MC, Verkman, AS
openaire +2 more sources
Aquaporin-4 and Cerebrovascular Diseases [PDF]
International Journal of Molecular Sciences, 2016 Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema.
Chu, Heling +7 more
openaire +2 more sources
Aquaporin 4 and neuromyelitis optica [PDF]
The Lancet Neurology, 2012 Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) and the evidence that AQP4-IgG is involved in the development of neuromyelitis optica revolutionised our understanding of the disease.
Marios C, Papadopoulos, A S, Verkman
openaire +2 more sources
Aquaporin-4 Expression in Meningioma Malignancy Progression
Brazilian Neurosurgery, 2023 Objectives The aim of the present study is to analyze if aquaporin-4 (AQP4) may also be a tumor progression marker for meningiomas. Methods This is an immunohistochemistry study realized at the Universidade de São Paulo, São Paulo, state of ...
Benedito Jamilson Araújo Pereira +5 more
doaj +1 more source
Aquaporin-4 expression in the human choroid plexus [PDF]
Cellular and Molecular Life Sciences, 2021 Abstract The choroid plexus (CP) consists of specialized ependymal cells and underlying blood vessels and stroma producing the bulk of the cerebrospinal fluid (CSF). CP epithelial cells are considered the site of the internal blood-cerebrospinal fluid barrier, show epithelial characteristics (basal lamina, tight junctions), and ...
Felix Deffner +7 more
openaire +3 more sources
Rinsho Shinkeigaku, 2008 In human body, there are thirteen water channels but their expression patterns are tissue specific. Aquaporin-4 (AQP4) is a predominantly expressed water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder, and mesial temporal lobe epilepsy.
Tani, Kazutoshi +2 more
openaire +3 more sources
Preparative scale production of functional mouse aquaporin 4 using different cell-free expression modes [PDF]
, 2010 The continuous progress in the structural and functional characterization of aquaporins increasingly attracts attention to study their roles in certain mammalian diseases.
Volker Dötsch +23 more
core +2 more sources
The Role of Aquaporins in Spinal Cord Injury
Cells, 2023 Edema formation following traumatic spinal cord injury (SCI) exacerbates secondary injury, and the severity of edema correlates with worse neurological outcome in human patients. To date, there are no effective treatments to directly resolve edema within
Terese A. Garcia +2 more
doaj +1 more source