Results 31 to 40 of about 26,122,743 (292)
European Radiology Experimental, 2021 Background Aquaporin-4 is a membrane channel protein that is highly expressed in brain astrocytes and facilitates the transport of water molecules. It has been suggested that suppression of aquaporin-4 function may be an effective treatment for reducing ...
Takuya Urushihata +9 more
doaj +1 more source
Aquaporin-4 and GPRC5B: old and new players in controlling brain oedema
Brain : a journal of neurology, 2023 Brain oedema is a life-threatening complication of various neurological conditions. Understanding molecular mechanisms of brain volume regulation is critical for therapy development.
E. Passchier +23 more
semanticscholar +1 more source
Aquaporin 4 and neuromyelitis optica [PDF]
The Lancet Neurology, 2012 Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) and the evidence that AQP4-IgG is involved in the development of neuromyelitis optica revolutionised our understanding of the disease.
Marios C, Papadopoulos, A S, Verkman
openaire +2 more sources
Brain aquaporin-4 expression in the rat septic model (immunohistochemical study)
Medičnì Perspektivi, 2022 The study aimed to determine aquaporin-4 expression in different brain regions was performed in Wistar rats subjected to cecal ligation and puncture (CLP) septic model.
T.V. Shulyatnikova, V.O. Tumanskiy
doaj +1 more source
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Brain : a journal of neurology, 2021 Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at the glia limitans, where it mediates water exchange across the ...
M. Salman +8 more
semanticscholar +1 more source
Aquaporin-4 Expression in Meningioma Malignancy Progression
Brazilian Neurosurgery, 2023 Objectives The aim of the present study is to analyze if aquaporin-4 (AQP4) may also be a tumor progression marker for meningiomas. Methods This is an immunohistochemistry study realized at the Universidade de São Paulo, São Paulo, state of ...
Benedito Jamilson Araújo Pereira +5 more
doaj +1 more source
Biochimica et Biophysica Acta - Biomembranes, 2021 Stroke is the second leading cause of death and the third leading cause of disability globally. Edema is a hallmark of stroke resulting from dysregulation of water homeostasis in the central nervous system (CNS) and plays the major role in stroke ...
N. Sylvain +7 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance By studying paired blood and deep cervical lymph node samples from patients with neuromyelitis optica spectrum disorders, our data provide evidence for a germinal center–based generation of aquaporin-4 antibodies.
V. Damato +22 more
semanticscholar +1 more source
Diagnostic utility of aquaporin-4 blood level in neonatal hypoxic ischemic encephalopathy [PDF]
Zagazig University Medical Journal, 2023 Background: In neonates, cerebral hypoxic-ischemia is the main cause of brain oedema which results in neurodevelopmental disfunction. After cerebral injury, Aquaporin-4 (AQP4) is reported to be overexpressed in the astrocytes. This study was conducted to
Ehab Elbanna +3 more
doaj +1 more source
Alzheimer's Research & Therapy, 2022 Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of ...
A. Arighi +12 more
semanticscholar +1 more source