Results 51 to 60 of about 9,338,478 (297)

Significance of molecular biomarkers in the diagnosis of neuromyelitis optica spectrum disorder [PDF]

Medicinski Podmladak
Discovery of antibodies to aquaporin-4 channels as a laboratory or molecular biomarker for neuromyelitis optica spectrum disorder contributed to a better understanding of the etiopathogenesis, with a clear separation of the clinical, neuroradiological ...
Andabaka Marko, Drulović Jelena, Novaković Ivana   +2 more
doaj   +1 more source

Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica. [PDF]

Sci Adv
Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system where pathogenic autoantibodies target the water channel aquaporin-4 on human astrocytes causing neurological impairment. Autoantibody binding leads to complement-dependent
Gupta M, Khandelwal NK, Nelson A, Hwang P, Pourmal S, Bennett JL, Stroud RM.   +6 more
europepmc   +2 more sources

Aquaporin-4 Autoantibodies in a Paraneoplastic Context [PDF]

Archives of Neurology, 2008
The neuromyelitis optica IgG autoantibody (NMO-IgG) is a validated biomarker for NMO and an emerging spectrum of inflammatory central nervous system-demyelinating disorders. Its antigen is the astrocytic water channel aquaporin-4; NMO-IgG has not been described in a cancer context.To report (1) neurologic and oncologic correlates for patients ...
Sean J, Pittock, Vanda A, Lennon
openaire   +2 more sources

The mechanisms underlying the actions of Xuefu Zhuyu decoction pretreatment against neurological deficits after ischemic stroke in mice: The mediation of glymphatic function by aquaporin-4 and its anchoring proteins

Frontiers in Pharmacology, 2022
Ischemic stroke (IS) has been associated with an impairment in glymphatic function. Xuefu Zhuyu Decoction (XFZYD) is widely used in the prevention and treatment of ischemic stroke.
Ting Yi, Ping Gao, Meng Hou, Huan Lv, Mengyuan Huang, Shanshan Gao, Jinrong He, Dongdong Yang, Weiyin Chen, Tianmin Zhu, Chang Yu, Fuyou Liu, Haiyan Yin, Shuoguo Jin   +13 more
doaj   +1 more source

Expression and localization of Aquaporin 1a in the sea-bass (Dicentrarchus labrax) during ontogeny

, 2011
The successful establishment of a species in a given habitat depends on the ability of each of its developing stages to adapt to the environment. In order to understand this process we have studied the adaptation of a euryhaline fish, the sea-bass ...
Guy Charmantier, Charline Abed, Giffard-Mena, Ivone, Guy eCharmantier, Boulo, Viviane, Viviane eBoulo, Ivone Giffard-Mena, Cramb, Gordon, Gordon Cramb, Gordon eCramb, Charmantier, Guy, Charline eAbed, Abed, Charline, Ivone eGiffard-Mena, Viviane Boulo   +14 more
core   +1 more source

Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier [PDF]

, 2015
To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and ...
Khorooshi, Reza; id_orcid, Mørch, Marlene Thorsen, Owens, Trevor; id_orcid, Berg, Carsten Tue, Asgari, Nasrin   +4 more
core   +1 more source

Physiological Roles of Aquaporin-4 in Brain

Physiological Reviews, 2013
Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While AQP4 has been implicated in a number of pathophysiological processes, its role in brain physiology has remained elusive.
Erlend A, Nagelhus, Ole P, Ottersen
openaire   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Astrocytic aquaporin 4 subcellular translocation as a therapeutic target for cytotoxic edema in ischemic stroke

, 2022
Brain edema is a common feature of several brain diseases (e.g., stroke, traumatic brain injury, hydrocephalus, brain cancer, and brain infections). Brain edema leads to increased intracranial pressure and worsens outcomes in ischemic stroke patients ...
Patabendige, A.
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source