Results 51 to 60 of about 38,738 (164)
Aquaporin-4 protein expression in normal canine brains
BMC Veterinary Research, 2021 Background Aquaporin-4 (AQP4) is in growing recognition as potential marker for cancer progression, differentiation and therapeutic intervention. No information is available about AQP4 expression in the normal canine brain.
Patricia Álvarez +3 more
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Aquaporin-3 and aquaporin-4 are sorted differently and separately in the trans-Golgi network. [PDF]
PLoS ONE, 2013 Aquaporin-3 (AQP3) and aquaporin-4 (AQP4) are homologous proteins expressed in the basolateral plasma membrane of kidney collecting duct principal cells, where they mediate the exit pathway for apically reabsorbed water.
Eva C Arnspang +3 more
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Frontiers in Cellular Neuroscience, 2022 Recent studies have revealed the critical role of AQP4 in the occurrence and development of gliomas. However, the role of AQP4 in immune regulation has not yet been reported.
Yu-Long Lan +7 more
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Orthogonal array formation by human aquaporin-4: Examination of neuromyelitis optica-associated aquaporin-4 polymorphisms [PDF]
Journal of Neuroimmunology, 2011 Pathogenic autoantibodies target aquaporin-4 (AQP4) water channels in individuals with neuromyelitis optica (NMO). Recently, allelic mutations were reported at residue 19 of AQP4 in three cases of NMO, and it was suggested that polymorphisms may influence disease by altering AQP4 supramolecular assembly into orthogonal arrays of particles (OAPs).
Jonathan M, Crane +4 more
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Aquaporin-4 Expression during Toxic and Autoimmune Demyelination
Cells, 2020 The water channel protein aquaporin-4 (AQP4) is required for a normal rate of water exchange across the blood–brain interface. Following the discovery that AQP4 is a possible autoantigen in neuromyelitis optica, the function of AQP4 in health and disease
Sven Olaf Rohr +6 more
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New isoforms of rat Aquaporin-4
Genomics, 2008 Aquaporin-4 (AQP4) is a brain aquaporin implicated in the pathophysiology of numerous clinical conditions including brain edema. Here we show that rat AQP4 has six cDNA isoforms, formed by alternative splicing. These are named AQP4a-f, where AQP4a and AQP4c correspond to the two classical M1 and M23 isoforms, respectively.
Moe, Svein Erik +5 more
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Aquaporin-4 and traumatic brain edema.
Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2010 Brain edema leading to an expansion of brain volume has a crucial impact on morbidity and mortality following traumatic brain injury as it increases intracranial pressure, impairs cerebral perfusion and oxygenation, and contributes to additional ischemic injuries.
XU, Miao, SU, Wei, XU, Qiu-ping
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Neuromyelitis optica - an update: 2007-2009
Annals of Indian Academy of Neurology, 2009 Neuromyelitis optica is an inflammatory demyelinating disorder of the central nervous system. The discovery of a specific antibody (NMO IgG /aquaporin-4 antibody) in patients with this condition has led to a marked revival of research on the disease ...
Jacob Anu
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Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019 Background Demyelinating diseases of the central nervous system associated with autoantibodies against aquaporin-4 and myelin-oligodendrocyte-glycoprotein are mediated by different immunopathological mechanisms compared to multiple sclerosis.
Livia S Hofer +13 more
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Annals of MedicineAquaporin 4 (AQP4) is abundant in the human brain and has an important role in brain homeostasis and diseases. AQP4 expression has been found to be associated with glioma malignancies.
Yu-Long Lan, Shuang Zou, Ruoli Chen
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