Results 61 to 70 of about 9,338,478 (297)

Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis - Fig 1

, 2017
Representative cases of aquaporin-4 antibody (AQP4 Ab)-positive (A−C) and -negative (D−F) optic neuritis in the left eye. Shown are optic nerve head maps (A, D) and GCC significance maps (B, E) from RTVue optical coherence tomography analyses, and gray ...
Sotaro Mori (3749752), Yoshiko Matsumoto (3749764), Takuji Kurimoto (3749761), Akiyasu Kanamori (3749749), Makoto Nakamura (199152), Yuko Yamada (3749758), Ichiro Nakashima (3574049), Kaori Ueda (3749755)   +7 more
core   +1 more source

Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy

Frontiers in Cellular Neuroscience, 2022
Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms underlying seizure activity have been intensely investigated.
Jenny I. Szu, Devin K. Binder
doaj   +1 more source

Aquaporin-4 and Parkinson’s Disease

International Journal of Molecular Sciences
The water-selective channel aquaporin-4 (AQP4) is implicated in water homeostasis and the functioning of the glymphatic system, which eliminates various metabolites from the brain tissue, including amyloidogenic proteins. Misfolding of the α-synuclein protein and its post-translational modifications play a crucial role in the development of Parkinson’s
Ksenia V. Lapshina, Irina V. Ekimova
openaire   +2 more sources

H95 Is a pH-Dependent Gate in Aquaporin 4 [PDF]

Structure, 2015
Aquaporin 4 (AQP4) is a transmembrane protein from the aquaporin family and is the predominant water channel in the mammalian brain. The regulation of permeability of this protein could be of potential therapeutic use to treat various forms of damage to the nervous tissue.
Kaptan, Shreyas, Assentoft, Mette, Schneider, Hans Peter, Fenton, Robert A; id_orcid 0000-0003-1623-199X, Deitmer, Joachim W, MacAulay, Nanna, de Groot, Bert L   +6 more
openaire   +5 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Aquaporin Expression Contributes to Human Transurothelial Permeability In Vitro and Is Modulated by NaCl

, 2012
It is generally considered that the bladder is impervious and stores urine in unmodified form on account of the barrier imposed by the highly-specialised uro-epithelial lining.
Lisa A Kirkwood, Kirkwood Lisa A., Rubenwolf, Peter C., Jennifer Southgate, Georgopoulos, Nikolaos T., Georgopoulos Nikolaos T., Rubenwolf Peter C., Kirkwood, Lisa A., Baker Simon C., Peter C Rubenwolf, Southgate, Jennifer, Southgate Jennifer, Baker, Simon C., Simon C Baker, Nikolaos T Georgopoulos   +14 more
core   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Optimization of laboratory diagnostics of neuromyelitis optica spectrum disorders: indications and algorithms [PDF]

Анналы клинической и экспериментальной неврологии
Neuromyelitis optica spectrum disorders are a group of autoimmune demyelinating diseases of the central nervous system characterized by severe exacerbations with development of residual neurological deficit. Anti-aquaporin-4 antibody is one of key factor
Taras O. Simaniv, Vladimir S. Krasnov, Sergey V. Lapin, Raisa T. Bembeeva, Denis S. Korobko, Elena A. Belko, Аlla A. Shabalina   +6 more
doaj   +1 more source

Glymphatic system and aquaporin‑4 in epilepsy

Acta Neurobiologiae Experimentalis, 2023
Over the past decade glymphatic concept has gained more and more interest. Despite some lacking data regarding structural and functional aspects, glymphatic system is widely considered the main mechanism of water and solutes transport in brain parenchyma, as well as waste clearance from the brain.
openaire   +2 more sources

Structural Determinants of Oligomerization of the Aquaporin-4 Channel [PDF]

Journal of Biological Chemistry, 2016
The aquaporin (AQP) family of integral membrane protein channels mediate cellular water and solute flow. Although qualitative and quantitative differences in channel permeability, selectivity, subcellular localization, and trafficking responses have been observed for different members of the AQP family, the signature homotetrameric quaternary structure
Kitchen, Philip; Conner, Matthew T.; Bill, Roslyn M.; Conner, Alex C.   +4 more
openaire   +5 more sources