Results 71 to 80 of about 99,139,021 (297)
, 2022 BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914) +25 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu +10 more
wiley +1 more source
Optimization of laboratory diagnostics of neuromyelitis optica spectrum disorders: indications and algorithms [PDF]
Анналы клинической и экспериментальной неврологииNeuromyelitis optica spectrum disorders are a group of autoimmune demyelinating diseases of the central nervous system characterized by severe exacerbations with development of residual neurological deficit. Anti-aquaporin-4 antibody is one of key factor
Taras O. Simaniv +6 more
doaj +1 more source
An optimized immunohistochemistry technique improves NMO-IgG detection: study comparison with cell-based assays. [PDF]
PLoS ONE, 2013 Cell-based assays (CBA) have increased the sensitivity of the neuromyelitis optica (NMO)-IgG/aquaporin-4-antibody detection compared to classical tissue-based indirect assays.
Romana Höftberger +10 more
doaj +1 more source
Zhongguo cuzhong zazhi, 2022 卒中后认知障碍是卒中的重要后遗症之一，从病理上可以分为血管性、退变性及混合性认知障碍。水通道蛋白4广泛分布于中枢神经系统，参与多种神经系统疾病和认知障碍的病理过程，但其参与卒中后认知障碍的具体机制目前尚未明确。本文综述水通道蛋白4通过参与调节神经炎症、突触可塑性以及β-淀粉样蛋白的积聚和清除过程在卒中后认知障碍中发挥的可能作用。 Abstract: Post-stroke cognitive impairment is one of the main sequelae of stroke ...
梁潇，钱海兵
doaj +1 more source
Glymphatic system and aquaporin‑4 in epilepsy
Acta Neurobiologiae Experimentalis, 2023 Over the past decade glymphatic concept has gained more and more interest. Despite some lacking data regarding structural and functional aspects, glymphatic system is widely considered the main mechanism of water and solutes transport in brain parenchyma, as well as waste clearance from the brain.
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, 2022 BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914) +25 more
core +1 more source
Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou +23 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective The objective of this scoping review was to synthesize evidence on the proportion of individuals living with Sjögren's disease who experience central nervous system (CNS) manifestations. Methods We searched MEDLINE (via PubMed) and Embase from 1980 through January 29, 2026, and the ECRI Guidelines Trust from 2020 through January 29, 2026 ...
Arun Varadhachary +21 more
wiley +1 more source
New isoforms of rat Aquaporin-4
Genomics, 2008 Aquaporin-4 (AQP4) is a brain aquaporin implicated in the pathophysiology of numerous clinical conditions including brain edema. Here we show that rat AQP4 has six cDNA isoforms, formed by alternative splicing. These are named AQP4a-f, where AQP4a and AQP4c correspond to the two classical M1 and M23 isoforms, respectively.
Moe, Svein Erik +5 more
openaire +3 more sources