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Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes [PDF]

open access: yesActa Neuropathologica Communications, 2020
Most cases of neuromyelitis optica spectrum disorders (NMOSD) harbor pathogenic autoantibodies against the water channel aquaporin 4 (AQP4). Binding of these antibodies to AQP4 on astrocytes initiates damage to these cells, which culminates in the ...
Irina Tsymala   +23 more
doaj   +5 more sources

Neuromyelitis optica pathogenesis and aquaporin 4 [PDF]

open access: yesJournal of Neuroinflammation, 2008
Neuromyelitis optica (NMO) is a severe, debilitating human disease that predominantly features immunopathology in the optic nerves and the spinal cord.
Kerr Douglas   +3 more
doaj   +3 more sources

Aquaporin 4 expression is downregulated in large bovine ovarian follicles

open access: goldJournal of Animal Reproduction and Biotechnology, 2020
Aquaporin channels (AQPs) are known to play an important role in the development of ovarian follicles through their function in water transport pathways. Compared to other AQPs, research on the role of AQP4 in female reproductive physiology, particularly
Chang-Woon Kim   +5 more
doaj   +3 more sources

Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4 [PDF]

open access: yesEuropean Cells & Materials, 2021
The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechanical loading. Changes in extracellular osmolality result in cell volume alterations, responsiveness to such changes is essential for cellular homeostasis ...
JW Snuggs, RAD Bunning, CL Le Maitre
doaj   +1 more source

α-Actinin 4 Links Vasopressin Short-Term and Long-Term Regulation of Aquaporin-2 in Kidney Collecting Duct Cells

open access: yesFrontiers in Physiology, 2021
Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho   +4 more
doaj   +1 more source

Water Channels Aquaporin 4 and -1 Expression in Subependymoma Depends on the Localization of the Tumors. [PDF]

open access: yesPLoS ONE, 2015
We analyzed aquaporin 4 and -1 expression in subependymomas, benign and slow growing brain tumors WHO grade I. Ten subependymoma cases were investigated, five of the fossa inferior and five of the fossa superior.Using immunohistochemistry, we observed ...
Susan Noell   +5 more
doaj   +1 more source

Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI

open access: yesEuropean Radiology Experimental, 2021
Background Aquaporin-4 is a membrane channel protein that is highly expressed in brain astrocytes and facilitates the transport of water molecules. It has been suggested that suppression of aquaporin-4 function may be an effective treatment for reducing ...
Takuya Urushihata   +9 more
doaj   +1 more source

Brain aquaporin-4 expression in the rat septic model (immunohistochemical study)

open access: yesMedičnì Perspektivi, 2022
The study aimed to determine aquaporin-4 expression in different brain regions was performed in Wistar rats subjected to cecal ligation and puncture (CLP) septic model.
T.V.  Shulyatnikova, V.O. Tumanskiy
doaj   +1 more source

Aquaporin-4 Expression in Meningioma Malignancy Progression

open access: yesBrazilian Neurosurgery, 2023
Objectives The aim of the present study is to analyze if aquaporin-4 (AQP4) may also be a tumor progression marker for meningiomas. Methods This is an immunohistochemistry study realized at the Universidade de São Paulo, São Paulo, state of ...
Benedito Jamilson Araújo Pereira   +5 more
doaj   +1 more source

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