Results 1 to 10 of about 38,816 (262)
Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes [PDF]
Acta Neuropathologica Communications, 2020 Most cases of neuromyelitis optica spectrum disorders (NMOSD) harbor pathogenic autoantibodies against the water channel aquaporin 4 (AQP4). Binding of these antibodies to AQP4 on astrocytes initiates damage to these cells, which culminates in the ...
Irina Tsymala +23 more
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Neuromyelitis optica pathogenesis and aquaporin 4 [PDF]
Journal of Neuroinflammation, 2008 Neuromyelitis optica (NMO) is a severe, debilitating human disease that predominantly features immunopathology in the optic nerves and the spinal cord.
Kerr Douglas +3 more
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Skull diploë is rich in aquaporin-4 [PDF]
Heliyon, 2020 Aquaporin-4 (AQP4) is a water conducting membrane integral protein channel which is widely expressed in the astrocyte system of the brain. During the development of the AQP4 positron emission tomography (PET) imaging agent [11C]TGN-020 (N-(1,3,4 ...
Yuji Suzuki +7 more
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Aquaporin-4 and Parkinson's Disease. [PDF]
Int J Mol SciThe water-selective channel aquaporin-4 (AQP4) is implicated in water homeostasis and the functioning of the glymphatic system, which eliminates various metabolites from the brain tissue, including amyloidogenic proteins. Misfolding of the α-synuclein protein and its post-translational modifications play a crucial role in the development of Parkinson’s
Lapshina KV, Ekimova IV.
europepmc +3 more sources
Co-occurrence of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and hepatocellular carcinoma: A case report [PDF]
Journal of International Medical ResearchNeuromyelitis optica spectrum disorder is a rare, relapsing autoimmune disease in which the immune system attacks the central nervous system, primarily the optic nerves and spinal cord.
Cheng Li, Weijing Liao, Di Long
doaj +2 more sources
Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica.
PLoS Medicine, 2007 BackgroundNeuromyelitis optica (NMO) is a demyelinating disease of the central nervous system (CNS) of putative autoimmune aetiology. Early discrimination between multiple sclerosis (MS) and NMO is important, as optimum treatment for both diseases may ...
Friedemann Paul +13 more
doaj +5 more sources
Aquaporin-3 and aquaporin-4 are sorted differently and separately in the trans-Golgi network. [PDF]
PLoS ONE, 2013 Aquaporin-3 (AQP3) and aquaporin-4 (AQP4) are homologous proteins expressed in the basolateral plasma membrane of kidney collecting duct principal cells, where they mediate the exit pathway for apically reabsorbed water.
Eva C Arnspang +3 more
doaj +6 more sources
Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4 [PDF]
European Cells & Materials, 2021 The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechanical loading. Changes in extracellular osmolality result in cell volume alterations, responsiveness to such changes is essential for cellular homeostasis ...
JW Snuggs, RAD Bunning, CL Le Maitre
doaj +1 more source
Frontiers in Physiology, 2021 Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho +4 more
doaj +1 more source
Aquaporin-4 autoimmunity [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes. The classic clinical manifestations of NMO are optic neuritis and longitudinally extensive transverse myelitis.
Zekeridou, Anastasia, Lennon, Vanda A.
openaire +2 more sources